Medicine Overview of Clinex Plus 1.2gm+.025gm/100gm Gel
Clinex Plus is a combination of two medicines, used to treat acne, which appears as spots or pimples on your face, chest or back. This medicine works by attacking the germs that cause them and rejuvenates sun damaged skin.
Clinex Plus is only meant for external use and should be used as advised by your doctor. You should normally wash and dry the affected area before applying a thin layer of the medicine. It should not be applied to broken or damaged skin. Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get it in these areas. It may take several weeks for your symptoms to improve, but you should keep using this medicine regularly. Do not stop using it as soon as your acne starts to get better. Ask your doctor when you should stop treatment.
Side effects like burning sensation, irritation, itching, redness, dryness, skin peeling or skin inflammation (dermatitis) may be seen at the application site, in some people. These are usually temporary and resolve on their own. Consult your doctor if they bother you or do not go away.
It is a safe medicine, but you should inform your doctor if you have any problems with your bowels (intestines), if you have ever had bloody diarrhea caused by taking antibiotics or if you are using any other medicines to treat skin conditions. Consult your doctor about using this medicine if you are pregnant or breastfeeding.
- Acne
- Application site reactions (burning, irritation, itching and redness)
- Dryness
- Skin peeling
- Dermatitis
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Retino AC Gel should be Applied as a thin layer onto clean, dry, unbroken skin affected by acne.
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Clean the area to be treated with water and a non-medicated soap, and let it dry for 20-30 minutes before applying the medicine.
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It may cause minor burning, stinging, or irritation when applied. Inform your doctor if this does not go away.
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Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get the cream in these areas.
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Avoid exposure to sunlight while using Retino AC Gel as it increases the sensitivity of your skin. Use protective measures such as sun-cream or protective clothing.
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Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
At first wash the face or affected area gently with warm water or soap.
When the skin is completely dried (about 30 minutes later) apply a pea-size amount of gel to your fingertip and spread it over your face.
Acne Vulgaris
Topical
Apply a pea-size amount of gel once daily preferably at bed time.
Treatment should be continued for 12 weeks.
<12 years old: Safety and efficacy not established
>12 years: Apply a pea-size amount of gel once daily preferably at bed time.
Clindamycin: Antibacterial agent that binds to the 50S ribosomal subunits of susceptible bacteria and prevents elongation of peptide chains by interfering with peptidyl transfer, thereby suppressing protein synthesis; reduces surface fatty acids on skin; exact mechanism of action in treating acne unknown
Tretinoin: Exact mechanism unknown; appears to cohesiveness of follicular epithelial cells with decrease microcomedo formation; also increases turnover of follicular cells to cause extrusion of comedones
Clindacin plus gel is not for oral, ophthalmic, or Intravaginal use.
Avoid exposure to sunlight and sunlamps. Wear sunscreen daily.
Lactation: excretion in milk unknown; use with caution
>10%
Erythema (21-35%),Scaling (13-19%),Itching (15-17%)
1-10%
Dryness (6%),Irritation (5%),Exfoliation (5%),Erythema (4%),Pruritus (2%),Stinging (2%),Burning (2%),Sunburn (1%),Dermatitis (1%)
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
Clindamycin: May enhance the action of neuromuscular blocking agents (e.g. atracurium). May antagonise the effects of parasympathomimetics. May competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid and chloramphenicol. Increased coagulation tests (prothrombin time/INR) and/or bleeding w/ vit K antagonists (e.g. warfarin, acenocoumarol, fluindione).
Tretinoin: Enhances percutaneous absorption of minoxidil. Increased risk of fatal thrombotic complications with antifibrinolytic. Increased tretinoin concentrations with azole antifungals. Enhances peeling action of sulphur, resorcinol, benzoyl peroxide, salicylic acid. Increased photosensitivity with photosensitising medications eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines and sulfonamides.
Potentially Fatal: Increased risk of intracranial pressure with tetracyclines.
