Medicine Overview of Leukin 50mg Tablet
Leukin 50 is used in the treatment of blood cancer. It shows its working by decreasing the number of red blood cells, which is produced by the body.
Leukin 50 can be taken with or without food or you can have it one hour before or 2 hours after the meal. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, vomiting, rash, diarrhea, and loss of appetite. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. You have to avoid driving or attention seeking activity if you experience dizziness while taking this medicine.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
- Blood cancer
- Nausea
- Vomiting
- Rash
- Decreased white blood cell count (neutrophils)
- Intestinal ulcer
- Anemia (low number of red blood cells)
- Increased bilirubin in the blood
- Low blood platelets
- Increased transaminase level in blood
- Diarrhea
- Loss of appetite
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Leukin 50 is used for the treatment of cancer of the blood.
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Take it with or without food.
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Do not drive or do anything requiring concentration until you know how it affects you.
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Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
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Your doctor may get regular blood and urine tests done to monitor your blood cells, kidney and liver function during treatment with this medicine.
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Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Acute lymphatic leukaemia, Crohn’s disease
Acute Lymphatic Leukemia
Induction: 2.5 mg/kg PO qDay; usually 100-200 mg PO qDay in average adult (other agents preferred)
May increase by 5 mg/kg/day after 4 weeks
Maintenance: 1.5-2.5 mg/kg PO qDay
Reduce dose by 75% if concomitant allopurinol administration
Crohn’s disease
Adult: Initially 1-1.5 mg/kg daily, may increase to 125 mg daily.
Hepatic impairment: Dosage may need to be reduced.
Acute Lymphatic Leukemia
Starting dose: 1.25-2.5 mg/kg (50-75 mg/m²) PO qDay
Maintenance: 1.5-2.5 mg/kg PO qDay in combination with methotrexate
Hepatic or renal dysfunction; monitor hepatic function periodically. Mercaptopurine is potentially carcinogenic. Thiopurine S-methyl transferase (TPMT) deficiency; porphyria.
Lactation: not known if excreted in breast milk, do not nurse
>10%
Elevated LFT’s (15%)
1-10%
Nausea (10%),Vomiting (10%),Stomatitis (3-10%),Thrombocytopenia (3-10%),Rash (1-3%),Diarrhea (1-3%),Dizziness (1-3%),Alopecia (1-3%),Leukopenia (1-3%)
Frequency Not Defined
Fatigue,Anorexia,Headache,Chills and fever,Chest pain,Mucositis,Upper respiratory infection,Cough,Ulceration of intestine,Ulcerative stomatitis,Myelosuppressionm,Decreased hematocrit,Hepatotoxicity,Decreased resistance to infections,Hyperuricemia,Nephrotoxicity,Increased risk of pancreatitis in pts with IBD,Hyperpigmentation of skin,Arthralgias,Eye discomfort,Tinnitus
Potentially Fatal: Myelosuppression; hepatotoxicity, cholestatic jaundice.
Anticoagulant action of warfarin may be inhibited by mercaptopurine. Enhanced toxicity with myelosuppressive drugs.
Potentially Fatal: Effects enhanced by allopurinol (reduce dose of mercaptopurine). Other hepatotoxic drugs (e.g. doxorubicin) potentiate toxicity.
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