Medicine Overview of Milran 12.5 12.5mg Tablet
Milran 12.5 is a prescription medicine used in the treatment of fibromyalgia (a condition in which there are generalized pain and tenderness in the body) and depression. It works by increasing the level of chemical messengers (serotonin and noradrenaline), helping in faster recovery.
Milran 12.5 may be taken with or without food. It is advised to take this medicine at a fixed time each day to maintain a consistent level in the blood. If you miss any doses, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly as it may worsen your symptoms.
Some common side effects of this medicine include nausea, vomiting, insomnia (difficulty sleeping), constipation, anxiety, decreased appetite, increased sweating, and sexual dysfunction. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. However, these side effects are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or bother you.
Before taking Milran 12.5, inform your doctor if you have any problems with your kidneys, heart, liver, or have a history of seizures (epilepsy or fits). Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or if you have any suicidal thoughts.
- Fibromyalgia
- Depression
- Nausea
- Vomiting
- Dizziness
- Insomnia (difficulty in sleeping)
- Constipation
- Anxiety
- Decreased appetite
- Increased sweating
- Sexual dysfunction
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Milran 12.5 helps in treating depression and anxiety.
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It may also be used to treat nerve pain from diabetes and some other forms of chronic pain.
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It may take 2 to 4 weeks for Milran 12.5 to start working. Keep taking it as prescribed.
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It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
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Avoid consuming alcohol when taking Milran 12.5 as it may cause excessive drowsiness and increase the risk of liver damage.
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It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
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Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
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Do not stop taking the medication suddenly without talking to your doctor.
Oral
Fibromyalgia
Adult:
Day 1: 12.5 mg once
Days 2-3: 25 mg/day (12.5 mg twice daily)
Days 4-7: 50 mg/day (25 mg twice daily)
After Day 7: 100 mg/day (50 mg twice daily)
Based on individual patient response, the dose may be increased to 200 mg/day (100 mg twice daily).
Depression
Adult: 50 mg bid.
Hepatic impairment
Mild or moderate (Child-Pugh A or B): No dosage adjustment required
Severe (Child-Pugh C): Caution advised
<17 years: Safety and efficacy not established
Renal impairment
Mild (CrCl 50-80 mL/min): No dosage adjustment required
Moderate (CrCl 30-49 mL/min): Use with caution
Severe (CrCl 5-29 mL/min): Reduce maintenance dosage by 50% (ie, to 50 mg/day divided q12hr)
End-stage renal disease (ESRD): Use not recommended
Patient w/ major depressive disorder or other psychiatric disorders, history of dysuria, controlled narrow-angle glaucoma, pre-existing HTN, tachyarrhythmias or other CV disease, history of seizure disorder or condition predisposing to seizures (e.g. brain damage, alcoholism). Avoid abrupt withdrawal. Severe hepatic and moderate to severe renal impairment including ESRD. Pregnancy and lactation.
Lactation: Drug is excreted in human milk; peak breast milk concentration is observed within 4 hours after maternal dose, and estimated infant exposure is 5% of maternal dose; limited data are available regarding infant exposure, but caution is advised
>10%
Nausea (37%),Headache (18%),Constipation (16%),Hot flush (12%),Insomnia (12%)
1-10% (selected)
Dizziness,Hyperhidrosis,Hypertension,Migraine,Palpitations,Tachycardia,Vomiting,Xerostomia
Frequency Not Defined
Abnormal bleeding,Depression (worsening),Serotonin syndrome,Suicidal thoughts,Withdrawal signs or symptoms
Potentially Fatal: Serotonin syndrome or neuroleptic malignant syndrome (NMS)-like reactions, suicidal thinking/behaviour.
Increased risk of bleeding w/ aspirin, NSAIDs, warfarin and other drugs that affect coagulation. Increased CNS effects w/ centrally-acting drugs (e.g. clomipramine). Increased risk of serotonin syndrome and NMS-like reactions w/ serotonergic drugs (e.g. tramadol), SSRIs, other selective serotonin-norepinephrine reuptake inhibitors, 5-HT1 receptor agonists (e.g. sumatriptan), antipsychotic agents and other dopamine antagonists. May inhibit antihypertensive effect of clonidine. May potentiate adverse haemodynamic effects w/ digoxin. Paroxysmal HTN and cardiac arrhythmia may occur when taken concurrently w/ epinephrine or norepinephrine.
Potentially Fatal: Increased risk of serotonin syndrome and NMS-like reactions w/ MAOIs (e.g. linezolid, IV methylene blue).
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