Ocuprost

Introduction
Ocuprost is a medicine used to reduce pressure in the eyes in people with glaucoma and ocular hypertension (high pressure in the eye). If the pressure in your eye is too high it can damage your sight, potentially leading to blindness. It works by helping fluid flow from inside the eye into the blood. Ocuprost is suitable for adults and children and can be used by itself or in combination with other eye medicines to reduce pressure. Follow the instructions given by your doctor and use this medicine regularly to get the most benefit. If you stop using it, pressure in the eye could increase and damage your sight. Never use a bottle if the seal is broken before you use it for the first time. If you wear contact lenses, make sure you remove them before instilling and wait for at least 15 minutes before putting them back. The most common side effects include eyelashes changes, eye pain and sensitivity to light. It may also cause blurred vision, dryness in the eye, a gradual change in color of the eye and other rare effects. If you get any side effects, talk to your doctor. Your doctor may be able to tell you ways of reducing or preventing some side effects or suggest another treatment. If your vision is blurred or you have other changes in sight for a time, do not drive until your vision is clear. This is usually a short-term side effect. Do not use this medicine if you are pregnant or trying to become pregnant, or if you are breastfeeding.

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Uses of Ocuprost
Glaucoma
Ocular hypertension
Side effects of Ocuprost
Common
Burning sensation in eye
Conjunctival hyperemia
Eye itching
Eye pain
Eyelash changes
Foreign body sensation
Itching
Stinging in the eyes
How to use Ocuprost
This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid.
How Ocuprost works
Ocuprost is a prostaglandin analogue. It works by increasing the outflow of aqueous humor, thereby lowering the increased eye pressure.
Quick Tips
Ocuprost helps lower high pressure in the eye and reduces the risk of vision loss.
For best results, put one drop once a day in the evening/night in the affected eye(s).
Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the drop.
Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
Remove contact lenses before using Ocuprost and allow at least 15 minutes before re-inserting them.
Ocuprost may cause brown pigmentation of the iris. This discoloration may be permanent.
Your eyelashes may become more dense and eyelid skin may darken. These changes should disappear after discontinuing Ocuprost.
Brief Description
Indication
Open-angle glaucoma, Ocular HTN
Adult Dose
Adult: As 0.005% eye drop: Instill 1 drop in affected eye once daily in every evening.

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Child Dose
Safety and efficacy not established

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Contraindication
Hypersensitivity.
Mode of Action
Latanoprost, a synthetic analogue of prostaglandin F2alpha, reduces the IOP by increasing the outflow of aqueous humour.
Precaution
Do not use within 5 min of thiomersal-containing preparations. Aphakia or pseudophakia with torn posterior lens cap or anterior chamber lenses; risk factors for cystoid macular oedema; brittle or severe asthma; history of intraocular inflammation; inflammatory, neovascular, angle-closure or congenital glaucoma; pregnancy, lactation. Remove contact lenses during use. Lactation: not known whether distributed into milk; use with caution

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Side Effect
>10% Increase in brown pigmentation of the iris (15.5%),Blurred vision (5-15%),Burning and stinging (5-15%),Foreign body sensation (5-15%),Itching (5-15%),Punctate epithelial keratopathy (5-15%),Conjunctival hyperemia (5-15%) 1-10% Upper respiratory tract infection/cold/flu (4%),Dry eye (1-4%),Excessive tearing (1-4%),Eye pain (1-4%),Lid crusting (1-4%),Lid edema (1-4%),Lid erythema (1-4%),Lid discomfort/pain (1-4%),Photophobia (1-4%),Chest pain/angina pectoris (1-2%),Muscle/joint/back pain (1-2%),Rash/allergic skin reactions (1-2%) <1% Conjunctivitis,Diplopia,Discharge from the eye Frequency Not Defined Dizziness,Headache _ Interaction Paradoxical elevations in IOP w/ other prostaglandins, prostaglandin analogs or prostaglandin derivatives.