Medicine Overview of Dacarzin 200mg/vial Injection
Dacarzin is used in the treatment of cancers of lymphatic system and malignant melanoma (a type of skin cancer). It may be also used to treat other conditions, as determined by the doctor.
Dacarzin is given as an injection into a vein by the healthcare professional, but better if injected at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine nausea, vomiting, injection site pain, and decreased white blood cell count. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Inform your doctor if you notice unusual bleeding or bruising, lack of energy, loss of appetite, and yellowing of eyes. Your doctor will advise you regular blood tests to check for these.
Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
- Malignant melanoma
- Hodgkin’s disease
- Nausea
- Vomiting
- Injection site pain
- Decreased white blood cell count
- Loss of appetite
-
Dacarzin is given as an injection into veins under the supervision of a doctor.
IV Preparation
Reconstitute with a 9.9 mL (100 mg vial) or 19.7 mL (200 mg vial) of SWI to obtain a 10 mg/mL soln
For infusion, dilute with D5W or NS up to 250 mL
IV Administration
IVP over 1 min (may be irritant & painful) OR infusion over 15-60 min
Intravenous
Metastatic melanoma
Adult: 2-4.5 mg/kg daily for 10 days, repeat at 4-wk intervals or 200-250 mg/m2 BSA daily for 5 days, repeat at 3-wk intervals or 850 mg/m2 BSA by infusion, repeat at 3-wk intervals.
Hodgkin’s disease
Adult: 150 mg/m2 BSA daily for 5 days, repeat every 4 wk or 375 mg/m2 BSA every 15 days in combination with other agents.
Soft tissue sarcoma
Adult: 250 mg/m2 BSA daily for 5 days repeated every 3 wk. Usually given with doxorubicin.
Hodgkin’s Disease
With other antineoplastics, eg ABVD
Dosage dependent on protocol150 mg/m² IV qDay for 5 days, repeat q4Weeks OR
375 mg/m² IV on Day 1; repeat every 15 Days
Hepatic or renal impairment. Pregnancy, lactation.
Lactation: not known if excreted in breast milk, do not nurse
>10%
Nausea (>90%),Vomiting(>90%),Injection site pain,Leukopenia,Thrombocytopenia
1-10%
Alopecia,Rash,Photosensitivity,Anorexia,Metallic taste,Flu-like syndrome
Frequency Not Defined
Anaphylaxis,Photosensitivity (rare),Cerebral hemorrhage,Seizure,Myelosuppression,Hepatic necrosis,Hepatic vein thrombosis,Hepatotoxicity
Potentially Fatal: Myelosuppression; hepatotoxicity, anaphylaxis.
Pregnancy Category: C
Lactation: not known if excreted in breast milk, do not nurse
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