Rezoven

Tablet - 10mg

Beximco Pharmaceuticals Ltd.

Generic: Adefovir Dipivoxil

1 Tablet

Original price was: Tk. 35.Current price is: Tk. 32.

Description

Medicine Overview of Rezoven 10mg Tablet

বাংলা

English

Indication

Adult: PO: (age > 12 year) 10 mg, once daily.

Administration

Increased risk of nephrotoxicity with nephrotoxic drugs e.g. aminoglycosides, ciclosporin, NSAIDs, vancomycin, tacrolimus. Ibuprofen increases bioavailability of adefovir.

Adult Dose

Pregnancy; elderly; child; renal or hepatic impairment. HIV antibody testing to be performed before initiation due to possible resistance development in untreated HIV infection. Increased risk of hepatotoxicity in females, obese patients and with prolonged treatment. Monitor renal function every 3 mth; hepatitis B biochemical, viral and serological markers every 6 mth and LFTs. Discontinue therapy if liver function worsens, severe hepatomegaly, steatosis or unexplained metabolic or lactic acidosis. Monitor hepatic function for several mth in patients whose antihepatitis therapy is discontinued as acute exacerbations of hepatitis may occur.

Lactation: Unknown if excreted in breast milk.

Renal Dose

Adefovir dipivoxil is an acyclic nucleoside reverse transciptase inhibitor. The diester function is hydrolyzed and subsequently phosphorylated to the active adefovir diphosphate. The active metabolite inhibits HBV DNA polymerase (reverse transcriptase) and hence inhibits viral replication. It can be used in patients with lamivudine-resistant hepatitis B.

Mode of Action

Taken orally, without regard to food.

Precaution

Chronic hepatitis B

Side Effect

Renal impairment: Haemodialysis patients: 10 mg every 7 days after dialysis.
CrCl (ml/min)
30-49 10 mg every 48 hr.
10-29 10 mg every 72 hr.

Pregnancy Category Note

>10%
Hematuria (11% vs 10% in placebo-treated),Asthenia (13% vs. 14% placebo),Hepatitis exacerbation (25%)

1-10%
Nausea (5%),Flatulence (4%),Diarrhea (3%)Dyspepsia (3%),Headache (9%),Rash (1-10%),Pruritus (1-10%),Dyspepsia (5-9%),Cough (6-8%),Rhinitis (5%)

Increased AST/ALT,Abnormal liver function,Renal failure,Renal insufficiency,Increased serum Cr (2-3%),Hypophosphatemia

Potentially Fatal: Lactic acidosis, severe hepatomegaly with steatosis, hepatotoxicity, nephrotoxicity.

Interaction