Medicine Overview of Avifanz 600mg Tablet
Avifanz belongs to a group of medicines called antiretrovirals. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). It helps to control HIV infection so your immune system can work better.
Avifanz reduces the chances of getting HIV-related complications and improves your lifespan. It can be taken empty stomach or with food and is prescribed in combination with other HIV medicines. Taking all these medicines regularly at the right times greatly increases their effectiveness and reduces the chances of HIV becoming resistant to them. It is important to keep taking them regularly until your doctor tells you it is safe to stop.
Common side effects of this medicine include headache, nausea, vomiting, stomach pain, fatigue, diarrhea, and rash. These are usually not serious but tell your doctor if they bother you or do not go away. Consult your doctor urgently if you experience a skin reaction or liver damage.
Before taking it, tell your doctor if you have any skin, liver or kidney problems. While using it, you may need regular blood tests to check your blood cell counts and liver function. Avoid drinking alcohol as it may increase your risk of liver damage. Pregnant or breastfeeding mothers should consult their doctor before using this medicine. Do not have unprotected sex or share personal items like razors or toothbrushes, if you are HIV positive. Talk to your doctor about safe ways like condoms to prevent HIV transmission during sex.
- HIV infection
- Headache
- Dizziness
- Agranulocytosis (deficiency of granulocytes in the blood)
- Insomnia (difficulty in sleeping)
- Sleepiness
- Vomiting
- Allergic reaction
- Nausea
- Abnormal dreams
- Fatigue
- Increased liver enzymes
- Anxiety
- Fever
- Itching
- Difficulty in paying attention
- Increased triglyceride level in blood
- Rash
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Avifanz is used in combination with other medicines for the treatment of HIV (human immunodeficiency virus).
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Take it on an empty stomach, preferably at bedtime to reduce side effects.
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Do not skip any doses and finish the full course of treatment even if you feel better.
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You can also pass on HIV or HBV to others. Don’t share needles or personal items that can have blood or body fluids on them.
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Your doctor may check your liver function regularly. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
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You might experience dizziness or abnormal dreams during initial days of treatment. Consult with a doctor if it bothers you or does not go away.
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Use a reliable method of contraception to prevent pregnancy while taking this medicine.
Oral
HIV infection
Adult: Combined with other antiretrovirals: 600 mg once daily. Dosing at bedtime recommended during 1st 2-4 wk of therapy to improve tolerability.
Hepatic impairment
Mild (Child-Pugh Class A): Dose adjustment not necessary; use caution
Moderate-to-severe (Child Pugh Class B or C): Not recommended
Oral
HIV infection
Child: Combined with other antiretrovirals: >3 yr,
10-14 kg: 200 mg;
15-19 kg: 250 mg;
20-24 kg: 300 mg;
25-32.4 kg: 350 mg;
32.5-39 kg: 400 mg;
>40 kg: 600 mg.
To be taken once daily.
Mild to moderate liver disease; renal impairment. Monitor liver enzymes and cholesterol. Discontinue if severe skin rash or fever develops; known or suspected hepatitis B or infection. History of mental illness or seizures; elderly. Pregnancy. Children.
Lactation: It is not known whether efavirenz is excreted in milk. It should not be administered to nursing mothers. The CDC advises HIV-infected women not to breast-feed to avoid postnatal transmission of HIV.
>10%
Total cholesterol increased (20-40%),Diarrhea (3-14%, children up to 39%),HDL increased (25-35%),Dizziness (28.1%),Rash (5-26%),Fever (children 21%),Depression (19%),Insomnia (16.3%),Cough (children 16%),Vomiting (3-12%),Anxiety (2-13%),Nausea (2-12%)
1-10%
Neutropenia (2-10%),Pruitis (9%),Impaired concentration (8.3%),Transaminases increased (2-8%),Somnolence (7.0%),Abnormal dreams (6.2%),Amylase increased (6%),Hyperglycemia (2-5%),Dyspepsia (4%),Abdominal pain (2-3%),Anorexia (2%),Hallucinations (1.2%)
Pregnancy Category: D
Lactation: Unknown if distributed in human milk; the CDC advises HIV-infected women not to breastfeed to avoid postnatal transmission of HIV
Hormonal contraceptives; antibacterial e.g. rifampicin, rifabutin, clarithromycin; enzyme inducers. St. John’s wort may decrease serum level. Ethanol (hepatic and CNS adverse effects).
Potentially Fatal: Life-threatening adverse effects when used with terfenadine, astemizole, cisapride, midazolam, triazolam and ergot alkaloids.
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