Medicine Overview of Cyporin 50mg/100ml Eye Drop
Introduction
Cyporin is used to prevent your body rejecting a new organ after a liver, kidney or heart transplant. It works by weakening your immune system so that your body does not attack the new organ. It can also be used to treat severe rheumatoid arthritis and a skin condition called psoriasis. The amount of Cyporin you take depends on your weight, medical condition and what you are taking it for. Your doctor will plan the correct dose for you. Do not change the dose without talking to your doctor. It can be taken with or without food. It is better
Uses of Cyporin
- Prevention of organ rejection in transplant patients
- Rheumatoid arthritis
- Psoriasis
Side effects of Cyporin
Common
- Headache
- Nausea
- Vomiting
- Increased hair growth
- High blood pressure
- Renal dysfunction
- Loss of appetite
- Diarrhea
- Tremor
How to use Cyporin
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Cyporin is to be taken with food.
How Cyporin works
Cyporin is an immunosuppressant. It works by suppressing your body’s immune response to help accept a newly transplanted organ (e.g., liver, kidney or heart). In rheumatoid arthritis, this immunosuppressive effect reduces inflammation (swelling) of joints and limits joint damage. In psoriasis, it works by reducing the activity of certain immune cells that cause overproduction of skin cells, thus improving scaling and redness.
What if you forget to take Cyporin?
If you miss a dose of Cyporin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
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Cyporin is used to prevent organ rejection in transplant patients.
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It is also used to treat arthritis and immune disorders of the eyes, lungs, muscles, skin, nerves, and blood vessels.
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It may take 3 to 4 months for the medication to work. Keep taking it as prescribed.
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Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Inform your doctor if you experience unexplained bruising or bleeding, sore throat, mouth ulcers, fever or general illness.
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Your doctor may monitor your kidney function regularly. Drink 8 to 10 glasses of water per day to help with your kidney function.
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Do not stop taking Cyporin without talking to your doctor first.
Brief Description
Indication
Dry eye
Adult Dose
Keratoconjuntivitis Sicca
1 drop twice daily approximately 12 hours apart in each eye
1 drop twice daily approximately 12 hours apart in each eye
May be used with artificial tears; allow 15-minute interval between products
Child Dose
<16 years
Safety and efficacy not established
Safety and efficacy not established
>16 years
Keratoconjuntivitis Sicca
1 drop twice daily approximately 12 hours apart in each eye
May be used with artificial tears; allow 15-minute interval between products
Contraindication
Cyclosporine is contraindicated in patients with active ocular infections and in patients with known or suspected hypersensitivity to any of the ingredients in the formulation.
Mode of Action
Ciclosporin is a strong immunosuppressant that acts mainly on the helper T-cells. It inhibits the activation of calcineurin and production of interleukin-2, thus reducing cell-mediated immune response. May act as immunomodulator to suppress tear production in keratoconjunctivitis sicca
Precaution
Cyclosporine eye drop should not be administered while wearing contact lenses. Patients with decreased tear production typically should not wear contact lenses. If contact lenses are worn, they should be removed prior to the administration of this formulation. Lenses may be reinserted 15 minutes following administration of Cyclosporine eye drop.
Lactation: Excretion in milk unknown; use with caution
Side Effect
>10%
Ocular burning (17%)
Ocular burning (17%)
Frequency Not Defined
Conjunctival hyperemia,Discharge,Epiphora,Eye pain,Foreign body sensation,Pruritus
Pregnancy Category Note
Pregnancy Clinical administration of cyclosporine ophthalmic emulsion 0.05% is not detected systemically following topical ocular administration, and maternal use is not expected to result in fetal exposure to the drug Oral administration of cyclosporine to pregnant rats or rabbits did not produce teratogenicity at clinically relevant doses Lactation Cyclosporine is known to appear in human milk following systemic administration, but presence in human milk following topical treatment has not been investigated; although blood concentrations are undetectable following topical administration of cyclosporine ophthalmic, caution should be exercised when cyclosporine ophthalmic multidose is administered to a nursing woman; the developmental and health
Interaction
Increased ciclosporin level by diltiazem, doxycycline, erythromycin, ketoconazole, methylprednisolone (high doses), nicardipine, verapamil, oral contraceptives. Drugs which reduce ciclosporin level are carbamazepine, isoniazid, phenobarbitone, phenytoin and rifampicin. Increased risk of convulsion when used concurrently with high-dose methylprednisolone.
Potentially Fatal: Additive nephrotoxicity when used with aminoglycosides, amphotericin B, ciprofloxacin, colchicine, melphalan, co-trimoxazole and NSAIDs.
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