Alkurin

Indication
Urinary tract infections, Prevent kidney stone, Prevent gout, Acidosis
Adult Dose
Alkalinizing Agent Urinary citrate <150 mg/day: 60 mEq/day PO (20 mEq with each meal) OR Urinary citrate >150 mg/day: 30 mEq/day PO (10 mEq with each meal) Maintenance Titrate dose to achieve urinary citrate 320-640 mg/day & urinary pH 6.0-7.0 (maximum dose 100 mEq/day)

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Child Dose
Safety & efficacy not established

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Contraindication
Hypersensitivity, hyperkalemia, Addison’s disease, anuria, uncontrolled DM, acute dehydration, adrenal insufficiency, renal insufficiency (GFR <0.7ml/kg/min) Delayed gastric emptying, esophageal compression, GI obstruction, concomitant anticholinergic Rx, peptic ulcer dz, active UTI Concomitant K+-sparing agents (e.g., triamterene, spironolactone, amiloride) _ Mode of Action Alkalinizes urine; citrate binds with urinary calcium. Precaution This medication should not be used ifpatient have (Addison's disease), current bladder infection, uncontrolled diabetes, severe heart disease (e.g., recent heart attack, heart damage), certain stomach/intestinal problems (diabetic gastroparesis, conditions decreasing gut movement, peptic ulcer, blockage), severe kidney disease (e.g., inability to make urine), potassium-restricted diet, high potassium levels, severe loss of body water (dehydration). Before using this medication, tell your doctor or pharmacist your medical history, especially of: low calcium levels, severe diarrhea, heart problems (e.g., irregular heartbeat, heart failure), kidney disease, stomach/gut problems (e.g., irritable bowel), severe tissue damage (e.g., severe burns). Before having surgery, tell your doctor or dentist that you are taking this medication. _ Side Effect Nausea, vomiting, diarrhea, and stomach pain may occur. Taking it after meals will help prevent these side effects. An empty tablet shell may appear in your stool. This is harmless because your body has already absorbed the medication. This drug may cause serious stomach or intestinal problems (e.g., bleeding, blockage, puncture). This medication may cause high potassium levels in the blood (hyperkalemia). A very serious allergic reaction to this drug is rare. _ Interaction K-sparing diuretics, anticholinergics & other drugs which delay GI transit time. _