Medicine Overview of Amantril 100mg Capsule
Adult: PO Influenza A 100 mg/day for 5 days. Prophylaxis of influenza A 100 mg/day for up to 6 wk. W/ influenza vaccination: up to 3 wk after vaccination.
Elderly: >65 yr: Daily dose of <100 mg or 100 mg given at intervals >1 day.
Herpes zoster 100 mg twice daily for 14 days, may continue for another 14 days if pain persists.
Parkinson’s disease100 mg/day, up to 100 mg twice daily 1 wk or more. Max: 400 mg/day.
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Enhances the adverse effects of antimuscarinics and levodopa. CNS stimulants, drugs that raise urinary pH.
The concurrent use of Amantadine hydrochloride with live attenuated influenza vaccine (LAIV) intranasal has not been evaluated.
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Patients with CV or liver disease, impaired renal function, recurrent eczema. Elderly. Withdrawal of the drug should be gradual.
Lactation: Drug enters breast milk; not recommended
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Oral
Influenza A treatment
Child: 1-9 years or <40 kg (any age): 5 mg/kg/day PO in single dose or divided q12 hr; not to exceed 150 mg/day
>10 years and <40 kg: 5 mg/kg/day PO divided q12hr
>10 years and >40 kg: 100 mg PO q12hr
NOTE: Because of resistance, amantadine is no longer recommended for prophylaxis or treatment of influenza A
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Parkinson’s disease, Influenza, herpes zoster, drug-induced extrapyramidal reactions
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Renal impairment:
CrCl (ml/min)
>35 100 mg daily.
15-35 100 mg every 2-3 days.
<15 Not recommended.
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1-10%
Agitation,Anorexia,Anxiety,Ataxia,Confusion,Constipation,Depression,Diarrhea,Dizziness,Dream abnormality,Dry nose,Fatigue,Hallucinations,Headache,Insomnia,Irritability,Livedo reticularis,Nausea,Nervousness,Orthostatic hypotension,Peripheral edema,Somnolence,Xerostomia
<1%
Amnesia,CHF,Decreased libido,Dyspnea,Eczematoid dermatitis,Euphoria,Hyperkinesis,Hypertension,Instances of convulsions,Leukopenia,Neutropenia,Oculogyric episodes,Psychosis,Rash,Slurred speech,Urinary retention,Visual disturbances,Vomiting,Weakness
Potentially Fatal: Congestive heart failure, convulsions.
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