Medicine Overview of Anastrol 1mg Tablet
Anastrol 1 is used alone or with other treatments, such as surgery or radiation, to treat early breast cancer in postmenopausal women. It can also be used as the first line treatment of advanced breast cancer that has spread within the breast or to other areas of the body.
Anastrol 1 belong to a class of drug called aromatase inhibitors, which decreases the amount of estrogen in the body. It should be taken with or without food, but take it at the same time every day to get the most benefit. It should be taken as your doctor’s advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. Swallow the tablets whole with a drink of water. You should take this medicine for as long as it is prescribed for you.
The most common side effects of the medicine include headaches, hot flushes, skin rash, loss of appetite, joint pain and osteoporosis (thinning of bone). If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.
Before taking this medicine, tell your doctor if you are not gone through menopause and still having menstrual periods, or you have a problem with the liver or kidney. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are pregnant or breastfeeding. Your doctor may perform some blood tests to check for vitamin D level or bone density.
- Breast cancer
- Headache
- Musculoskeletal (bone, muscle or joint) pain
- Nausea
- Osteoporosis
- Skin rash
- Weakness
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Anastrol 1 is used for the treatment of hormone dependent breast cancer in postmenopausal women.
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Take it at the same time everyday.
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It may cause weakness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
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Nausea may occur on starting treatment with this medicine but should go away with time. If nausea is bothersome, take it after meal.
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Your doctor may regularly check your Vitamin D level and bone mineral density and suggest supplements, if needed.
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Do not take Anastrol 1 if you are pregnant or breastfeeding.
Oral
Advanced or locally advanced breast cancer, Adjuvant treatment in early breast cancer
Adult: In postmenopausal women: 1 mg daily. Adjuvant treatment may be continued for up to 5 yr.
Hepatic Impairment
Mild-to-moderate impairment or stable hepatic cirrhosis: Dose adjustment not necessary
Severe hepatic impairment: Not studied
Moderate or severe hepatic impairment, hyperlipidaemias. Laboratory test for menopause if status is doubtful. Bone mass density test should be conducted at the start of the therapy and at regular intervals thereafter.
Lactation: Unknown whether drug is excreted in milk; not recommended given potential for serious adverse reactions in nursing infants
>10%
Hot flashes (12-36%),Vasodilation (25-36%),Fatigue (19%),Mood disturbances (19%),Nausea and vomiting (19%),Weakness (16-19%),Arthritis (17%),Pain (17%),Arthralgia (2-15%),Pharyngitis (14%),Depression (13%),Hypertension (2-13%),Bone pain (11%),Increased cough (11%),Osteoporosis (11%),Rash (8-11%)
1-10%
Accidental injury (10%),Back pain (10%),Fracture (10%),Headache (10%),Insomnia (10%),Peripheral edema (10%),Dyspnea (8-10%),Abdominal pain (9%),Infection (9%),Lymphedema (9%),Diarrhea (8-9%),Constipation (7-9%),Breast pain (8%),Dizziness (8%),Urinary tract infection (8%),Chest pain (7%),Dyspepsia (7%),Paresthesia (5-7%),Anxiety (6%),Cataracts (6%),Flu syndrome (6%),Sinusitis (6%),Vulvovaginitis (6%),Xerostomia (6%),Breast neoplasm (5%),Bronchitis (5%),Cyst (5%),Diaphoresis (5%),Neoplasm (5%),Vaginal bleeding (5%),Fractures of spine, hip, or wrist (4%),Ischemic cardiovascular disease (4%),Vaginal hemorrhage (4%),Vaginitis (4%),Leukorrhea (3-4%),Deep vein thrombosis (2%),Endometrial cancer (intact uterus at baseline) (2%),Ischemic cerebrovascular event (2%),Weight gain (2%),Lethargy (1%)
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