Anthisan

Indication
Pruritic skin disorders
Adult Dose
Topical/Cutaneous Hypersensitivity reactions, Pruritic skin disorders Adult: Apply 2% cream on affected areas.

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Contraindication
Severe liver disease; premature infants or full-term neonates; eczema (topical).
Mode of Action
Mepyramine is an ethylenediamine derived antihistamine with antimuscarinic and sedating properties.
Precaution
Pregnancy; lactation; severe CV disorders; asthma; drowsiness; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly; epilepsy. May affect ability to drive and operate machinery. Broken skin (topical).
Side Effect
Sedation; antimuscarinic effects, CNS depression and disturbances; occasionally, paradoxical CNS stimulation; psychomotor impairment; headache; palpitations and arrhythmias; convulsions, sweating, myalgia, paraesthesias, extrapyramidal symptoms, tremor, sleep and GI disturbances, hypersensitivity reactions and blood dyscrasias; hypotension; hair loss; tinnitus.
Interaction
increased effects with CNS depressants (e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and neuroleptics). Additive effects with other antimuscarinics (e.g. TCAs, atropine).