Medicine Overview of Aristocort Oral Paste
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Indication
Mouth ulceration
Adult Dose
Mouth/Throat
Mouth ulceration
Adult: A small amount (about 0.6 cm) of the 0.1% paste is pressed onto the lesion without rubbing until a thin film develops.
Apply 2 or 3 times daily, preferably after meals.
Re-evaluate if recovery does not occur after 7 days of treatment.
Mouth ulceration
Adult: A small amount (about 0.6 cm) of the 0.1% paste is pressed onto the lesion without rubbing until a thin film develops.
Apply 2 or 3 times daily, preferably after meals.
Re-evaluate if recovery does not occur after 7 days of treatment.
Contraindication
Untreated systemic fungal, bacterial, viral or parasitic infection, hypersensitivity.
Mode of Action
Triamcinolone has mainly glucocorticoid activity. It suppresses the migration of polymorphonuclear leukocytes and reduces capillary permeability thereby decreasing inflammation.
Precaution
Diabetes; hypertension, renal and liver impairment; glaucoma; psychosis; delayed tissue healing; cirrhosis; heart failure; recent MI; hypothyroidism; osteoporosis; peptic ulceration; thromboembolic disorders. Monitor height in children on prolonged therapy. Avoid rapid drug withdrawal. Elderly, children, pregnancy, lactation.
Side Effect
Local burning, itching, irritation, GI upsets; increased fragility of mucosa of the mouth.
Interaction
Lowering of plasma salicylates levels. Increased risk of GI bleeding and ulceration with NSAIDs. Antagonised blood glucose-lowering effects of the antidiabetics. Increased risk of hyperkalaemia with amphotericin B, beta agonists, beta-blockers, potassium-depleting diuretics, theophylline. Increased clearance of the triamcinolone with ciclosporin, carbamazepine, phenytoin, barbiturate, rifampicin. Infections may develop if given with live vaccines.
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