Asorin

Introduction
Asorin is an antiplatelet medicine used to treat and prevent heart attacks, strokes and heart-related chest pain (angina). It helps to prevent the formation of blood clots in your blood vessels. It is a very widely used medicine for heart protection. Asorin is usually best taken with food otherwise it may upset your stomach. The dose that is right for you depends on what you are taking it for and how well it helps your symptoms. You should take it as recommended by your doctor. The most common side effects of this medicine are heartburn or upset stomach, nausea, and vomiting. These are not usually serious but if you are worried, ask your doctor about ways of reducing or preventing them. This medicine may sometimes cause you to bleed more easily (for example you may get nosebleeds or bruises). Before taking it, you should let your doctor know if you have ever had a prolonged problem when your blood did not clot properly or if you have had an ulcer or bleeding in your stomach or intestine. To make sure this medicine is safe for you, also tell your doctor if you have trouble with your liver or kidneys, have high blood pressure or asthma. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Pregnant or breastfeeding women should consult their doctor before starting treatment. It is usually not recommended in later stages of pregnancy and while breastfeeding. Avoid drinking alcohol while you are taking this medicine. Heavy drinking can increase your risk of stomach bleeding.

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Uses of Asorin
Heart attack
Stroke
Angina (heart-related chest pain)
Side effects of Asorin
Common
Heartburn
Increased bleeding tendency
Nausea
Upset stomach
Vomiting
How to use Asorin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Asorin is to be taken with food.
How Asorin works
Asorin is a non-steroidal anti-inflammatory drug (NSAID) with anti-platelet action. It works by preventing platelets from sticking together which decreases the formation of harmful blood clots. This lowers the chance of heart attack or stroke.
Quick Tips
Asorin helps prevent future heart attack and clot-related (ischemic) stroke.
It is generally well-tolerated with minimum side effects.
Take it with food to avoid an upset stomach.
It may make you bleed more easily. Be careful while shaving, using sharp objects, or cutting fingernails or toenails.
Inform your doctor if you notice blood in your vomit or have black/tarry stools.
Stop taking Asorin and tell your doctor if you have ringing in your ears, unusual bleeding, or nausea or vomiting that does not go away.
Brief Description
Indication
PO Prophylaxis of myocardial infarction Adult: 75-300 mg once daily. Lower doses should be used in patients receiving ACE inhibitors. Stent implantation Adult: 300 mg 2 hr before procedure followed by 150-300 mg/day thereafter. Mild to moderate pain and fever Adult: 150-300 mg repeated every 4-6 hr according to response. Max: 4 g/day. Pain and inflammation associated with musculoskeletal and joint disorders Adult: Initial: 2.4-3.6 g/day in divided doses. Usual maintenance: 3.6-5.4 g/day. Monitor serum concentrations. Hepatic impairment: Severe liver disease: Not recommended

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Administration
Alcohol, corticosteroids, analgin, phenylbutazone and oxyphenbutazone may increase risk of GI ulceration. Aspirin increases phenytoin levels. May antagonize actions of uricosurics and spironolactone. Potentially Fatal: May potentiate effects of anticoagulants, methotrexate and oral hypoglycaemics.

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Adult Dose
Patients with history of asthma, angioedema, urticaria or rhinitis, nasal polyp, severe renal or hepatic impairment, lactation. Lactation: Drug enters breast milk; decision should be made regarding whether to discontinue nursing or to discontinue drug, taking into account importance of drug to mother.

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Child Dose
Pregnancy category: C; D in 3rd trimester
Renal Dose
Aspirin is an analgesic, anti-inflammatory and antipyretic. It inhibits cyclooxygenase, which is responsible for the synthesis of prostaglandin and thromboxane. It also inhibits platelet aggregation.
Contraindication
PO Juvenile rheumatoid arthritis Child: <25 kg: 60-100 mg/kg/day PO divided q6-8hr (maintain serum salicylate at 150-300 mcg/mL) >25 kg: 2.4-3.6 g/day Pain & Fever <12 years 10-15 mg/kg PO q4hr, up to 60-80 mg/kg/day _ Mode of Action Should be taken with food. Precaution Fever, Headache, Pain/inflammation, Acute coronary syndrome, TIA, MI, Stroke Side Effect Renal impairment CrCl >10 mL/min: Dose adjustment not necessary CrCl <10 mL/min: Not recommended _ Pregnancy Category Note GI disturbances; prolonged bleeding time, rhinitis, urticaria and epigastric discomfort; angioedema, salicylism, tinnitus; bronchospasm. Potentially Fatal: Gastric erosion, ulceration and bleeding; severe, occasionally fatal exacerbation of airway obstruction in asthma; Reye's syndrome (children <12 yr). Hepatotoxicity; CNS depression which may lead to coma; CV collapse and resp failure; paroxysmal bronchospasm and dyspnoea. _ Interaction Hypersensitivity (attacks of asthma, angioedema, urticaria or rhinitis), active peptic ulceration; pregnancy (3rd trimester), children <12 yr, patients with haemophilia or haemorrhagic disorders, gout, severe renal or hepatic impairment, lactation. _