Avomine

Introduction
Avomine used in the treatment of various allergic conditions like runny nose, sneezing, congestion, itching and watery eyes. It also treats nausea, vomiting and insomnia (difficulty in sleeping) in adults and used as a sedative (sleep causing) in children (for 5 years and above). Avomine should be taken with or without food, but take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. In case, you have missed any doses than it is better to take the next dose as soon as you remember it. However, you should never take a double dose. you must inform your doctor if symptoms does not get improve within 7 days of treatment. The most common side effects of this medicine include dry mouth, blur vision, headache, and feeling dizzy. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It makes skin more sensitive towards sunlight. use sunscreen or wear protective clothing before going out. Before taking this medicine, let your doctor know if you have glaucoma or have asthma issues or have high blood pressure. Inform your doctor if you are pregnant, or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Generally, it is advised to avoid alcohol while on treatment.

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Uses of Avomine
Nausea
Vomiting
Side effects of Avomine
Common
Dryness in mouth
Blurred vision
Headache
Dizziness
How to use Avomine
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Avomine may be taken with or without food, but it is better to take it at a fixed time.
How Avomine works
Avomine is an antiallergic medication. When your body is exposed to an allergen (pollen, animal dander, house dust etc.), it produces a chemical called histamine. This causes watery eyes, runny or blocked nose, sneezing, skin rashes, itching etc. Avomine works by blocking the action of histamine, thereby relieving these symptoms. It also works directly on several areas of the brain to prevent nausea/vomiting and help you feel more relaxed.
What if you forget to take Avomine?
If you miss a dose of Avomine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
Avomine helps treat nausea and vomiting.
It may also be used for the short-term treatment of sleeping difficulties (insomnia) in adults and as a sedative in children.
Use caution while driving or doing anything that requires concentration as Avomine can cause dizziness and sleepiness.
Do not drink alcohol while taking this medication as it may cause increased sleepiness.
It may make your skin more sensitive to sunlight. Avoid exposing your skin to strong sunlight, use a sunscreen lotion or make sure your skin is protected with clothing.
Do not take it for longer than 7 days. If your symptoms worsen or do not improve after 7 days, talk to your doctor.
Stop taking it at least three days before taking an allergy test as it can affect the test results.
Brief Description
Indication
Nausea and vomiting, Motion sickness, Vertigo
Administration
May be taken with or without food.
Adult Dose
Oral Nausea and vomiting Adult: As teoclate: 25 mg at night, may be increased to 50 or 75 mg at night or to 25 mg bid/tid, if needed. Max: 100 mg daily. Prophylaxis of motion sickness Adult: As teoclate: 25 mg at night or 25 mg 1-2 hr before travelling.

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Child Dose
Oral Nausea and vomiting Child: As teoclate: 5-10 yr: 12.5-37.5 mg daily. Prophylaxis of motion sickness Child: As teoclate: 5-10 yr: 12.5 mg daily starting either on the night before long journeys or 1-2 hr before short journeys.

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Renal Dose
Renal impairment: Dose reduction may be required.

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Contraindication
Hypersensitivity, coma, porphyria, cardiac disease, hypokalaemia, intra-arterial or SC inj.
Mode of Action
Promethazine, a phenothiazine derivative, blocks postsynaptic dopaminergic receptors in the brain and has a strong alpha-adrenergic blocking effect. It competitively binds to H1-receptors.
Precaution
Patient w/ asthma, bronchitis or bronchiectasis; severe coronary artery disease, narrow-angle glaucoma, epilepsy, bladder neck or pyloro-duodenal obstruction, Reye’s syndrome, bone marrow depression, Hepatic and renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause marked drowsiness, if affected, do not drive or operate machinery. Avoid prolonged exposure to sunlight. Monitoring Parameters Monitor mental status; signs and symptoms of tissue injury (IV inj). Lactation: Not known whether drug crosses into breast milk; discontinue drug, or do not nurse

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Side Effect
Neuroleptic Malignant Syndrome (NMS); CV effects (e.g. bradycardia, tachycardia, transient HTN, hypotension; jaundice, blood dyscrasias, extrapyramidal effects; IV inj: Severe tissue injury (e.g. gangrene), pain and burning, paralysis, thrombophlebitis, severe spasm of distal vessels, necrosis. Sedation, Confusion, Disorientation, Blurred vision, Hallucinations, Dystonias, Catatonic states, Euphoria, Excitation, Impotence, Urinary retention Potentially Fatal: Resp depression and apnoea esp in childn.

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Interaction
Masks ototoxicity of aminoglycoside antibiotics. May enhance the sedative effects of CNS depressants like alcohol, hypnotics, barbiturates and opioids. Potentially Fatal: Ventricular arrhythmias when used with drugs that prolong QT interval.

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