Azonam

Introduction
Azonam is an antibiotic used to prevent or treat a wide variety of bacterial infections. This may include infections of the urinary tract, blood, brain, ear, skin, and soft tissue, abdomen, bone, windpipe and lungs. Azonam is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. It should be used regularly at evenly spaced time intervals as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening. Rash, vomiting, nausea, and diarrhea may be seen as the most common side effects. Temporary pain, swelling, and redness at the injection site may also occur at the injection site. Consult your doctor if any of these side effects persist or if your condition does not improve despite treatment. Inform your doctor if you have any previous history of allergy or heart problems before taking this medicine. Pregnant or breastfeeding women should consult their doctor before using this medicine.

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Uses of Azonam
Severe bacterial infections
Side effects of Azonam
Common
Rash
Injection site reactions (pain, swelling, redness)
Vomiting
Nausea
Diarrhea
How to use Azonam
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Azonam works
Azonam is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Quick Tips
You have been prescribed Azonam for the treatment of bacterial infections.
It is given by an injection or drip into a vein or into a muscle in the buttock or thigh.
Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn’t stop or if you find blood in your stools.
Inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking this medicine.
Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
Bone and joint infections, Intra-abdominal infections, Lower respiratory tract infections, Meningitis, Septicaemia, Skin and soft tissue infections, Pelvic infections, Gonorrhoea, Cystitis, Urinary tract infections, Cystic fibrosis
Administration
Reconstitution: IM: Reconstitute vial w/ at least 3 mL of sterile water for inj, sterile bacteriostatic water for inj, normal saline, or bacteriostatic NaCl per g of aztreonam; immediately shake vigorously. IV: Bolus inj: Reconstitute vial w/ 6-10 mL of sterile water for inj. Infusion: Reconstitute vial w/ at least 3 mL of sterile water for inj per g of aztreonam; immediately shake vigorously. Then further dilute in an appropriate soln for infusion to a final concentration of <2%. _ Adult Dose Adult: IV/IM Gm-ve infections 1-8 g/day in divided doses depending on severity. Max: 8 g/day. UTI 0.5-1 g 8-12 hrly. IM Cystitis; Gonorrhoea 1 g as a single dose. _ Child Dose Child: IV, IM 90–120 mg/kg/day q6–8hr Infants >1 wk: 30 mg/kg every 6 or 8 hr

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Renal Dose
Renal impairment CrCl 10-30 mL/min: 1-2 g loading dose, then 50% of usual dosage CrCl <10 mL/min: 1-2 g loading dose, then 25% of usual dosage _ Contraindication Hypersensitivity to aztreonam. Mode of Action Aztreonam inhibits bacterial cell wall synthesis due to its high affinity for penicillin-binding protein 3 (PBP-3) of gm-ve bacteria. It is highly resistant to hydrolysis by many narrow-spectrum β-lactamases. It is also active against most Enterobacteriaceae (including E. coli, Citrobacter, Enterobacter, Klebsiella, Proteus, Providencia, Salmonella, Serratia, Shigella, Yersinia spp. and Morganella morganii). Precaution History of β-lactam hypersensitivity. Renal and hepatic impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor for signs of anaphylaxis during 1st dose; periodic LFT. Consider measuring FEV1 prior to initiation of inhalation therapy. Lactation: Drug is excreted in milk in low concentrations; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing) _ Side Effect >10% Injection Pain at injection site (12%; children); (2%; adults) Increase in serum transaminases (4-6%) Neutropenia (3-11%, children); (<1%, adults) 1-10% Rash (4%),Thrombocytopenia (4%, children); (<1% adults),Diarrhea (1%),Nausea (1%),Vomiting (1%),Fever (<1%) < 1% Abnormal taste,Anaphylaxis,Anemia,Angioedema,Aphthous ulcer,Breast tenderness,Bronchospasm,Clostridium difficile-associated diarrhea (CDAD),Confusion,Diplopia,Dizziness,Dsypnea,Electrocardiographic changes (transient),Erythema multiforme,Eosinophilia,Fever,Flushing,Halitosis,Headache,Hepatitis,Hypotension,Insomnia,Jaundice,Leukocytosis,Neutropenia,Pancytopenia,Seizures,Thrombocytopenia,Tinnitus,Tongue numbness,Toxic epidermal necrolysis,Urticaria,Vaginitis,Vertigo,Weakness,Wheezing Potentially Fatal: Clostridium difficile-associated diarrhoea from mild diarrhoea to fatal colitis. _ Pregnancy Category Note Pregnancy category: B Lactation: Drug is excreted in milk in low concentrations; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing) _ Interaction Concurrent use w/ oral anticoagulants may increase prothrombin time.