Bestron

Introduction
Bestron This medication is a combination product containing conjugated estrogens and bazedoxifene (an estrogen agonist/antagonist).Bestron is used by women with a uterus to help reduce symptoms of menopause (such as hot flashes, vaginal dryness) and to prevent bone loss (osteoporosis) after menopause. Conjugated estrogens are hormones which help to decrease menopausal symptoms caused by the body making less estrogen. Bazedoxifene is not a hormone, but works by acting like estrogen (as a selective estrogen receptor modulator or SERM) in some parts of the body. The bazedoxifene in this medication helps to preserve bone mass and reduces the risk of cancer of the uterus which can be caused by using estrogen.

_
Brief Description
Indication
Use to treat moderate to severe vasomotor symptoms associated with menopause, as well as to prevent postmenopausal osteoporosis.
Administration
Take this medication orally with or without food as advised by your doctor, generally once a day. To avoid stomach distress, you can take it with or after a meal. Swallow the tablets whole. Do not break or chew the tablets.
Adult Dose
Should be taken once a day.
Child Dose
Not recommended for use on children.
Renal Dose
It should be used with caution in patients with kidney disease. Dose adjustment of it may be needed. Please consult your doctor.
Contraindication
Women with undiagnosed abnormal uterine bleeding, known, suspected, or past history of breast cancer, known or suspected estrogen-dependent neoplasia, active deep venous thrombosis, pulmonary embolism, or history of these conditions, active arterial thromboembolic disease, hypersensitivity (e.g., anaphylaxis, angioedema) to estrogens, bazedoxifene, or any ingredients, known hepatic impairment, or other known thrombophilic disorders are all contraindications.
Mode of Action
It is a combination of conjugated estrogens and bazedoxifene. Conjugated estrogens and bazedoxifene activate estrogen receptors α and β. Bazedoxifene is an estrogen agonist/antagonist that operates as an agonist in some estrogen-sensitive tissues but an antagonist in others,
Precautions
Estrogen therapy is not recommended for the prevention of cardiovascular disease or dementia. Women with uterus who use unopposed estrogens are more likely to develop endometrial cancer.
Side Effect
High blood pressure, blood clots, liver and thyroid issues, fluid retention, hypocalcemia, dementia, breast lumps, atypical vaginal bleeding, severe headaches, muscle spasms, weakness and weariness, nausea, diarrhea, throat pain, disorientation, and so on.
Pregnancy & Lactation Category Note
Should not be used in women who are or might become pregnant.Breastfeeding mothers should avoid using this product. It is unknown if this medication is excreted in human milk. The delivery of estrogen to nursing moms has been found to reduce the quantity and quality of milk.
Interaction
There were no medication interaction studies done with this pill. Estrogens are partially metabolized by CYP3A4. Concurrent use of this tablet with CYP3A4 inhibitors may increase conjugated estrogen exposure and hence the risk of endometrial hyperplasia.
Storage Conditions
Keep out of the reach of children.Do not store above 30°C. Keep away from light and out of the reach of children. After opening foil pouch, product must be used within 60 days.