Caprolycin

Introduction
Caprolycin is used to treat bleeding. It helps to prevent bleeding after major heart surgery and it also controls bleeding in thrombocytopenia (accompanying aplastic anemia), liver cirrhosis, urinary bleeding and some types of cancer. Caprolycin works by preventing the breakdown of clots which leads to stoppage of bleeding. This injection must be administered under the supervision of a healthcare professional. You should not take it if you have any known allergy from this injection. The most common side effects may be injection site reactions such as pain, swelling and redness or pain in the muscle, bone or joint. Inform your doctor if you have undergone any cardiac surgery or you are suffering from any liver disease. This injection is safe to use in pregnant or breastfeeding mothers. It is also safe to use in patients suffering from kidney diseases. Caution is advised to drive after the administration of this injection.

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Uses of Caprolycin
Bleeding
Side effects of Caprolycin
Common
Nasal congestion (stuffy nose)
Tiredness
Musculoskeletal (bone, muscle or joint) pain
Injection site reactions (pain, swelling, redness)
How to use Caprolycin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Caprolycin works
Caprolycin prevents the breakdown of clots and stops bleeding.
What if you forget to take Caprolycin?
If you miss a dose of Caprolycin, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
Caprolycin helps prevent or reduce heavy bleeding post surgery and in conditions such as heavy periods, dysfunctional uterine bleeding, and nosebleeds.
It is given as a slow injection into a vein.
Your doctor will prescribe the lowest effective dose for the shortest possible time necessary to relieve your symptoms.
Your doctor may monitor your vision regularly while you are taking this medicine.
Inform your doctor if you have a history of kidney or liver disease.
Brief Description
Indication
Intravenous Treatment and prophylaxis of haemorrhage Adult: Initially, 4-5 g as a 2% solution over 1 hr followed by a 1 g/hr infusion continued for up to 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr. Oral Treatment and prophylaxis of haemorrhage Adult: Initially, 4-5 g, followed by 1-1.25 g every hr for about 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr. Patients with haemophilia undergoing dental extraction Adult: Initially, 6 g immediately after the procedure, followed by 6 g every 6 hr for up to 10 days.

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Administration
Increased risk of hypercoagulability with OC and oestrogens.
Adult Dose
Renal or cardiac disorders. Urinary tract bleeding, haematuria of upper urinary tract origin; veno-occlusive hepatic disease, skeletal myopathy, neonates. Monitor creatinine phosphokinase. Avoid admin with factor IX complex concentrates. Pregnancy and lactation. Lactation: not known whether excreted in breast milk, use caution

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Renal Dose
Aminocaproic acid inhibits the action of plasminogen activators and, to a lesser extent, it also has some antiplasmin activity.
Mode of Action
IV Administration Initial 5 g in 250 mL over 1 hr, each subsequent gram in 50-100 mL at 1 g/hr Rapid injection undiluted into a vein is not recommended Continue for about 8 hr or until bleeding has been controlled Oral May be taken with or without food. May be taken w/ meals to prevent GI upset.

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Precaution
Haemorrhage, Missed abortion, Hereditary hemorrhagic telangiectasia,Traumatic hyphema, Dental bleeding, Hemophilia A, Postoperative bleeding, Systemic hyperfibrinolysis
Side Effect
Renal impairment: Dosage reduction may be required.
Pregnancy Category Note
Oedema, headache, malaise, allergic and anaphylactic reactions, anaphylaxis, bradycardia, hypotension, peripheral ischaemia, thrombosis, abdominal pain, diarrhoea, nausea, vomiting, agranulocytosis, coagulation disorder, leukopaenia, thrombocytopaenia, increased CPK, muscle damage, myalgia, myopathy, myositis, rhabdomyolysis, confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope, dyspnoea, nasal congestion, pulmonary embolism, pruritus, rash, tinnitus, decreased vision, watery eyes, increased BUN, dry ejaculation. Potentially Fatal: Cardiac and hepatic damage.

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Interaction
Bleeding due to disseminated intravascular coagulation. Rapid IV administration.