Carbate

Indication
Prophylaxis of uterine atony and excessive bleeding after caesarean section
Adult Dose
Intravenous Prophylaxis of uterine atony and excessive bleeding after caesarean section Adult: Single dose of 100 mcg given over 1 min after delivery.

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Contraindication
Do not administer before delivery. Vascular disease esp coronary artery disease; hepatic or renal disease.
Mode of Action
Carbetocin is a synthetic analogue of oxytocin reported to have a longer duration of action.
Precaution
Monitor BP in eclampsia and preeclampsia for up to 8 hrs. Inadequate uterine contraction (do not repeat treatment). Epilepsy; migraine; asthma.
Side Effect
Nausea; vomiting; abdominal pain; pruritus; flushing; feeling of warmth; hypotension; headache; tremor; back pain; dizziness; metallic taste; anaemia; sweating; chest pain; dyspnoea; chills; tachycardia; anxiety.
Interaction
Vasoconstrictors in conjunction with caudal block anaesthesia; cyclopropane anaesthesia.