Carbestop

Introduction
Carbestop is a medicine used to control excessive bleeding from the uterus, that may occur after the childbirth. It stimulates contraction of the uterine muscles thus, helps to control post-delivery bleeding. Carbestop is given as an injection deep into the muscles under the medical supervision of a doctor. It is only given at the hospital sitting, so do not self- administered the medicine. The dose and how often you take it depends on what you are taking it for. You should take this medicine for as long as it is prescribed for you. The most common side effects of this medicine include vomiting, flushing, hot flushes, headache, and chills. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. If you notice dizziness, avoid driving or attention seeking activity. Before taking this medicine, tell your doctor if you have ever had heart disease, or you have high or low blood pressure or have liver or kidney disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Always remember, it is only giver after delivery not during pregnancy.

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Uses of Carbestop
Post-delivery bleeding
Side effects of Carbestop
Common
Vomiting
Flushing (sense of warmth in the face, ears, neck and trunk)
Headache
Nausea
Chills
Diarrhea
Placental retention
Cough
How to use Carbestop
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Carbestop works
Carbestop stimulates contraction of the uterine muscles, helping to control post-delivery bleeding.
Quick Tips
Carbestop increases the contraction of your womb which helps to control excessive bleeding after delivery.
It is injected deep in to a muscle by your doctor or nurse.
It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
It may cause an increase in body temperature. This will return to normal few hours after the last injection.
Inform your doctor if you have problems with your heart, lung, kidney or liver.
Brief Description
Indication
Pregnancy termination in the 2nd trimester (Abortion), Postpartum Uterine Bleeding
Adult Dose
Intramuscular Pregnancy termination in the 2nd trimester/Abortion Adult: Initially, 250 mcg. Alternatively, initiate w/ test dose of 100 mcg. May be repeated at 1.5- to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if uterine contractility is inadequate. Max: 12 mg. Max duration: 2 days. Intramuscular Postpartum haemorrhage Adult: Initially, 250 mcg by deep inj. May be repeated every 15-90-min. Max: 2 mg.

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Contraindication
Acute pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.
Mode of Action
Carboprost, a synthetic analogue of naturally occurring prostaglandin F2α, stimulates uterine contractility, resulting in expulsion of the products of conception. It is also used to induce abortion between 13-20 wk of pregnancy. It produces myometrial contractions responsible for placental haemostasis.
Precaution
History of glaucoma or raised IOP Asthma, hypertension/hypotension, cardiovascular disease Transient fever observed with treatment possibly as a result of carboprost’s effect on hypothalamic thermoregulation Caution in patients with anemia, jaundice, renal impairment, hepatic impairment diabetes or epilepsy To decrease GI side effects pretreatment or concomitant use with antiemetic and antidiarrheal agents recommended Not for IV Rare cases of cardiovascular collapse reported with prostaglandins Lactation: Excretion in milk unknown

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Side Effect
Nausea (1/3 patients), Vomiting (~2/3 patients),Diarrhea (~2/3 patients) Nervousness,Epistaxis,Sleep disorder,Hyperthermia,Flushing,Asthma,Wheezing,Coughing,Chest pain,Hypertension,Syncope,Palpation,Tachycardia,Chest tightness,Anxiety,Chills/shivering,Dizziness,Drowsiness,Dystonia,Faintness,Headache,Lethargy,Lightheadedness,Vertigo,Rash,Breast tenderness,Dysmenorrhea-like pain,Hot flashes,Dry throat.Taste alterations,Uterine bleeding (excessive) Local: injection site pain Backache,Leg cramps,Muscular pain,Parethesia,Blurred vision,Eye pain,Eyelid twitching,Tinnitus,Bronchospasm,Dyspnea,Hiccups

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Pregnancy Category Note
Pregnancy Category: C Lactation: Excretion in milk unknown

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Interaction
May potentiate effect of other oxytocics.