Cinaryl Plus

Introduction
Cinaryl Plus is used to treat vertigo. It is a combination medicine which acts by relaxing vascular smooth muscles of the blood vessels of the ear and improves the blood circulation. It also blocks the action of a chemical messenger that is responsible for lightheadedness in vertigo. Cinaryl Plus should be taken with food to avoid stomach upset. Take this medicine as advised by your doctor and preferably at a fixed time each day. Do not skip any doses, but if you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment and never stop this medicine suddenly without talking to your doctor. Some common side effects of using this medication are dryness of mouth and stomach pain. To overcome dryness, it is advised to drink more water, always carry sugar candy or maintain oral hygiene. It can cause dizziness and sleepiness as well. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. Usually, it is advisable to avoid alcohol while taking the medicine. Before taking this medicine, it is better to inform your doctor if you are suffering from peptic ulcer, asthma, or low blood pressure. You must inform your doctor if you are taking any other medicines regularly, as it may affect the way this medicine works for you. Pregnant or breastfeeding mothers should consult their doctor before taking this medicine.

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Uses of Cinaryl Plus
Vertigo
Side effects of Cinaryl Plus
Common
Drowsiness
Headache
Stomach pain
Dryness in mouth
How to use Cinaryl Plus
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cinaryl Plus is to be taken with food.
How Cinaryl Plus works
Cinaryl Plus is a combination of two medicines: Cinnarizine and Dimenhydrinate. Cinnarizine is a calcium channel antagonist which works by preventing constriction of the blood vessels of the inner ear. This improves the microcirculation of the ear. Dimenhydrinate is an antiallergic. It blocks the action of a chemical messenger (histamine) that is responsible for light-headedness in vertigo.
Quick Tips
Cinaryl Plus helps relieve symptoms of vertigo such as nausea, vomiting, dizziness or spinning sensation.
Take it with food to avoid stomach upset.
It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.
Do not drink alcohol while taking this medicine as it may cause increased sleepiness.
Do not take this medicine if you are pregnant or breastfeeding.
Do not stop taking Cinaryl Plus without talking to your doctor first.
Brief Description
Indication
Nausea and vomiting, motion sickness, vertigo, meniere’s disease, peripheral vascular diseases, cerebrovascular disorders, vestibular disorders

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Administration
Should be taken with food.
Adult Dose
Oral Peripheral vascular disease Adult: 75 mg bid or tid. Motion sickness Adult: 30 mg 2 hr before travel then 15 mg 8 hrly during the journey if necessary. Cerebrovascular disorders Adult: 75 mg once daily. Vertigo and vestibular disorders Adult: 30 mg tid or 75 mg 1-2 times daily.

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Child Dose
Oral Motion sickness Child: 5-12 yr 15 mg 2 hr before travel then 7.5 mg 8 hrly during the journey as necessary. Vertigo and vestibular disorders Child: 5-12 yr 15 mg tid.

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Contraindication
Proven hypersensitivity to the drug. Parkinson’s disease. Childn and neonates.
Mode of Action
Cinnarizine has calcium-channel blocking activity selective for arterial smooth muscle. It also has some antihistamine activity. Cinnarizine acts as a labyrinthine sedative. It also improves microcirculation by reducing ischaemia-induced blood viscosity. Dimenhydrinate is an antihistamine which also has antimuscarinic and central sedative action. It also exerts a depressant action on hyperstimulated labyrinthine function.

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Precaution
Hypotension; pregnancy; lactation; elderly. May impair ability to drive or operate machineries.
Side Effect
Extrapyramidal symptoms sometimes associated with severe depression. Drowsiness, headache, GI upsets, unsteadiness, headache; rarely skin and hypersensitivity reactions, dry mouth, blurred vision, urinary difficulty or retention, constipation and increased gastric reflux, fatigue. Hypolipidaemic effect.
Interaction
Cinnarizine: CNS depressant effect enhanced with alcohol. Action potentiated by domperidone. Dimenhydrinate: Physically incompatible with aminophylline, hydrocortisone, phenothiazines and some barbiturates in solution. Potentially Fatal: Potentiates the sedative effects of CNS depressants including alcohol, barbiturates, opioid analgesics, sedatives and neuroleptics. MAOIs, atropine, TCAs enhance antimuscarinic effect. Masks ototoxicity produced by aminoglycoside antibiotics.

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