Clonipres 0.3

Introduction
Clonipres 0.3 is a medicine used in the treatment of hypertension (high blood pressure). It lowers the blood pressure by relaxing the blood vessels. Lowering the blood pressure helps to prevent future stroke and heart attack. Clonipres 0.3 is also used to prevent migraine and hot flushes in women during menopause. This medicine can be taken with or without food but it is better to take it at the same time every day. You should always take this medicine as advised by the doctor and should never stop it without consulting the doctor. Most people with high blood pressure do not feel ill, but if you stop taking this medicine, your condition could get worse. This may lead to your blood pressure rising up again and increase your risk of heart disease and stroke. You should monitor your blood pressure regularly while taking this medicine. Common side effects of this medicine include dizziness, headache, nausea, fatigue, dry mouth, and constipation. Consult your doctor if these side effects bother you. Before taking this medicine, it is better to let your doctor know if you are suffering from any kidney or liver disease. Also, pregnant women and breastfeeding mothers should consult a doctor before taking it.

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Uses of Clonipres 0.3
Hypertension (high blood pressure)
Side effects of Clonipres 0.3
Common
Dizziness
Sleepiness
Dryness in mouth
Constipation
How to use Clonipres 0.3
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clonipres 0.3 may be taken with or without food, but it is better to take it at a fixed time.
How Clonipres 0.3 works
Clonipres 0.3 is an alpha-2 agonist. It works by relaxing blood vessels which makes the heart more efficient at pumping blood around the body.
What if you forget to take Clonipres 0.3?
If you miss a dose of Clonipres 0.3, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
Clonipres 0.3 may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
It may cause you to feel lightheaded especially when you stand up (orthostatic hypotension). Rise slowly if you have been sitting or lying down.
It may cause dryness of eyes. Take caution while using contact lenses.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Hypertension, Anxiety disorders, Migraine, Panic disorder, Menopausal flushing, Hypertensive crisis, Cancer pain
Administration
May be taken with or without food.
Adult Dose
Oral Hypertension Adult: Initially, 50-100 mcg tid, increased every 2nd or 3rd day according to response. Maintenance: 300-1,200 mcg daily, some may require >1,800 mcg daily. Max: 2,400 mcg daily. Prophylaxis of migraine; Menopausal flushing Adult: 50 mcg bid, increased to 75 mcg bid if no remission after 2 wk.

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Child Dose
<12 years old: Safety and efficacy not established _ Renal Dose Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) <10 50-75% of usual dose. _ Contraindication Hypersensitivity. Disorders of cardiac pacemaker activity and conduction. Pregnancy and lactation. Mode of Action Clonidine stimulates alpha-2 receptors in brain stem which results in reduced sympathetic outflow from the CNS and a decrease in peripheral resistance leading to reduced BP and pulse rate. It does not alter normal haemodynamic response to exercise at recommended dosages. Precaution Withdraw gradually, renal impairment, tasks that require mental alertness. Cerebrovascular disease, ischaemic heart disease, MI. IV inj should be administered slowly. Occlusive peripheral vascular disorders, history of depression. Lactation: Distributed in breast milk; caution advised _ Side Effect >10% Skin reactions; patch (15-50%),Dry mouth (40%),Somnolence (19-38%),Headache (19-29%),Fatigue (13-24%),Drowsiness (33%),Dizziness (13-16%),Hypotension, epidural (45%),Postural hypotension, epidural (32%),Anxiety (11%) 1-10% Constipation (10%),Sedation (10%),Nausea/vomiting, PO (5%),Malaise (3%),Orthostatic hypotension (3%),Anorexia, PO (1%),Abnormal LFTs (1%),Rash (1%),Weight gain, PO (1%) Frequency Not Defined Children with ADHD Upper respiratory tract infection,Irritability,Throat pain,Nightmares,Insomnia,Emotional disorder,Constipation,Nasal congestion Potentially Fatal: Transient hypertension or profound hypotension, respiratory depression, convulsion. Clonidine withdrawal syndrome could be life threatening. Bradycardia, coma and disturbances in conduction (in individuals with preexisting diseases of SA/AV nodes, overdose or on digitalis).

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Pregnancy Category Note
Pregnancy category: C Lactation: Distributed in breast milk; caution advised

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Interaction
Hypotensive action may be potentiated by diuretics and vasodilators. Effects of clonidine antagonised by TCAs and centrally-acting alpha-blockers. May enhance toxicity due to digitalis, lithium. May antagonise oral hypoglycaemics. Potentially Fatal: Hypnosedatives, antihistamines and alcohol may cause excessive drowsiness in patients on clonidine. Withdrawal of clonidine in patients receiving noncardioselective ?-blockers may result in rebound BP. Acute severe hypotension following concomitant administration of clonidine and chlorpromazine or haloperidol.

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