Medicine Overview of Corzil 80 F/C 80mg Tablet
Corzil 80 F/C is a medicine used to treat high blood pressure and heart disease. Lowering blood pressure helps to prevent future heart attack and stroke. This medicine is also effective in preserving kidney function in patients with diabetes.
Corzil 80 F/C can be prescribed either alone or in combination with other medicines. It may be taken with or without food during the day or at night. However, try to take it at the same time each day to get the most benefit. It is important to continue taking it regularly even if you feel well or if your blood pressure is controlled. Most people with high blood pressure do not feel ill, but if you stop taking this medicine, your condition could get worse. This is a widely used medicine and is considered safe for long-term use.
Making some changes in your lifestyle will also help lower your blood pressure. These may include regular exercise, losing weight, smoking cessation, reducing alcohol intake, and reducing the amount of salt in your diet as advised by your doctor. This medicine is tolerated well by most patients and has few side effects. Dizziness, particularly after the first dose, is known to occur in some people. This may be associated with headache. Let your doctor know if these side effects bother you or do not go away. No weight gain has been seen with the regular use of this medicine.
Before taking this medicine, let your doctor know if you have any kidney or liver problems. Pregnant or breastfeeding mothers should also consult their doctor before taking it. Your doctor may check your kidney function, blood pressure and potassium levels in your blood at regular intervals while you are taking this medicine.
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- Hypertension (high blood pressure)
- Heart failure
- Prevention of heart attack and stroke
- Dizziness
- Muscle damage
- Diarrhea
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Take it at the same time every day to help you remember to take it.
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It can make you feel dizzy for the first few days. Rise slowly if you have been sitting or lying down for a long time.
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Your doctor may get regular tests done to monitor the level of urea, creatinine, and potassium in your blood.
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Avoid taking anti-inflammatory medicines such as ibuprofen along with this medicine without consulting your doctor.
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Do not take Corzil 80 F/C if you are pregnant or breastfeeding.
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Do not stop taking it suddenly without talking to your doctor.
Adult: Initially 40 mg once daily. May be increased to a max of 80 mg once daily as necessary.
Elderly: No dose adjustment is necessary in elderly patients
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Renal Impairment
No dose adjustment is required with mild-to-severe renal impairment or end-stage renal disease.
Patients with moderate-to-severe renal impairment are more likely to report high serum creatinine values.
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Angiotensin II blocker; displaces angiotensin II from AT1 receptor and may lower blood pressure by antagonizing AT1-induced vasoconstriction, aldosterone release, catecholamine release, arginine vasopressin release, water absorption, and hypertrophic responses.
May induce more complete inhibition of renin-angiotensin system compared with ACE inhibitors; does not affect response to bradykinin.
Inhibits the pressor effects of an angiotensin II infusion in a dose-related manner.
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Correct vol or salt depletion prior to administration. Renal (moderate to severe) & hepatic (severe) impairment. Pregnancy (1st trimester) & lactation. Childn <18 yr.
Monitor serum K in patients taking K-sparing diuretics, salt substitutes containing K & drugs that increase K levels (eg heparin) & creatinine levels in patients w/ renal impairment & type 2 DM. Aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy.
Lactation: unknown whether distributed in breast milk, decide on alternate antihypertensive therapy or do not breastfeed
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1-10%
Diarrhea (2%)
<1%
Nausea,Asthenia,Fatigue,Muscle spasm,Dizziness,Postural hypotension,Cough
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Reversibly increases serum conc & toxicity of lithium; attenuated antihypertensive effects & risk of worsening of renal function may occur w/ NSAIDs. Hyperkalemia w/ K-sparing diuretics & K supplements.
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