Medicine Overview of Demarin 600mg Tablet
Demarin is a pain relieving medicine. It provides relief to pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout, and juvenile arthritis. It also helps in relieving muscle and joint pain, headache, fever, toothache, and menstrual cramps.
Demarin should be taken with food to avoid stomach upset and reduce side effects. In general, you should try to use the smallest amount necessary to control your symptoms, for the shortest possible time. You should take this medicine regularly while you need it. Try not to miss doses as it will become less effective if you do.
The common side effects of this medicine include vomiting, stomach pain, nausea, and indigestion. If any of these side effects do not resolve with time or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.
This medicine is generally considered safe but is not suitable for everybody. Before you take it, you should tell your doctor if you have kidney problems, asthma, blood disorders or drink a lot of alcohol. Also, tell your doctor what other medicines you are taking to make sure you are safe. It is best to avoid drinking alcohol while using this medicine.
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- Fever
- Headache
- Arthralgia (joint pain)
- Muscle pain
- Dental pain
- Post operative pain
- Pain during menstruation
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Gout
- Vomiting
- Nausea
- Indigestion
Avoid Demarin with herbs/food with anti-platelet activity such as alfalfa, anise, bilberry, grape seed, green tea, turmeric, fenugreek, garlic, ginger.
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You have been prescribed Demarin to relieve pain and inflammation.
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Take it with food or milk to prevent upset stomach.
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Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
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Do not take indigestion remedies (antacids) within two hours of taking Demarin.
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Avoid consuming alcohol while taking Demarin as it can increase your risk of stomach problems.
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Inform your doctor if you have a history of heart disease or stroke.
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Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for long-term treatment.
Osteoarthritis
Initial in mild to moderate disease: 600mg PO qDay
Usual in moderate to severe disease: 1200mg PO qDay
Maximum 1,800 mg/day or 26 mg/kg/day, whichever is lower, divided PO q12hr
Rheumatoid Arthritis
1200mg PO qDay (individualize)
Maximum 1,800 mg/day or 26 mg/kg/day, whichever is lower, divided PO q12hr
Hepatic Impairment
Caution in patients with severe liver impairment
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Juvenile Rheumatoid Arthritis
<6 years
Safety and efficacy not established
>6 years
22-31 kg: 600 mg PO qDay
32-54 kg: 900 mg PO qDay
>55 kg: 1200 mg PO qDay
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Renal Impairment
Severe renal impairment or on dialysis: 600 mg PO qDay; may increase to 1200 mg/day; monitor closely
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Be alert for ulceration and bleeding in patients treated chronically. History of serious GI events, alcoholism, smoking, other factors known to be associated with peptic ulcer. Elderly or debilitated patients. Uncompensated cardiac failure, history of hypertension, cardiac decompensation, chronic diuretic therapy, conditions predisposing to fluid retention. Renal and hepatic impairment. Underlying coagulation defects or patients who are undergoing surgical procedures where a high degree of haemostasis is required. Pregnancy (avoid in 3rd trimester) and lactation.
Lactation: not known whether excreted in breast milk; effect on infant unknown
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Common
Edema,Rash,Abdominal pain,Anorexia,Constipation,Diarrhea,Indigestion,Nausea/Vomiting,GI ulcer,Gross bleeding with perforation,Heartburn,Anemia,LFT’s increased.Tinnitus,Dysuria, Increased frequency of urination,Myocardial infarction (<2%)
<1%
Hypertension (<1%),Palpitations (<1%),Thrombotic tendency observations,Erythema multiforme (rare),Scaling eczema,Stevens-Johnson syndrome (rare),Toxic epidermal necrolysis (rare),Cerebrovascular accident,Gastrointestinal hemorrhage (<1%),Agranulocytosis (rare),Leukopenia (<1%),Thrombocytopenia (<1%),Hepatitis (rare),Jaundice, Liver failure,Anaphylactoid reaction (<1%),Amblyopia (<1%),Hearing loss (<1%),Acute renal failure (rare),Hematuria (rare),Interstitial nephritis (rare),Bronchospasm,Serum sickness due to drug (rare)
Potentially Fatal: Anaphylactoid reactions, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, severe hepatic reactions.
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