Medicine Overview of Diavix 150mg+300mg Tablet
Diavix is a combination of two antiretrovirals. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome).
Diavix restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual. The medicine can be taken with or without food. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. It is important to complete the full course of the treatment until your doctor advises you to stop it.
Some of the the most common side effects of this medicine are nausea, diarrhea, headaches, and fatigue. These side effects are generally temporary, but if they persist or become serious inform your doctor. This medicine can also make you feel dizzy or sleepy, so it is advised to avoid driving. Drinking plenty of fluid can help you to cope up with this side effect, so stay hydrated.
Before starting with the treatment, you should consult your doctor if you are pregnant or breastfeeding, or have any health condition. Your doctor may suggest regular laboratory tests to check your blood counts, kidney and liver functions, and other health conditions. If you are HIV positive, you should not breastfeed or share personal belongings like razors or toothbrushes. Consult your doctor to know about safe sex methods in order to prevent transmission of HIV during intercourse.
- HIV infection
- Nausea
- Headache
- Diarrhea
- Fatigue
- Cough
- Feeling of discomfort
- Nasal congestion (stuffy nose)
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Diavix is a combination of two medicines which slows down or stops the progression of HIV infections.
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It may also be used for preventing HIV and should be started within 72 hours of exposure to HIV.
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Take it with food, as this increases the absorption of the medicine into the body.
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Diavix may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
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Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time.
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Always practice safe sex while taking Diavix. Do not share needles or personal items that can have blood or body fluids on them.
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It may cause weakening of your bones. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor.
Oral
HIV infection
Adult: Each tab contains lamivudine 150 mg and zidovudine 300 mg:
>30 kg: 1 tab bid.
Avoid administering to patients < 30 kg
Hepatic impairment: Severe: Not recommended, use separate preparations.
HIV Infection
<12 years: Not recommended; fixed-dose combination cannot be adjusted for children
> 12 years and < 30 kg: Not recommended
>12 years and >30 kg: As adults; 150 mg/300 mg (1 tablet) PO q12hr
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<50 Not recommended, use separate preparations
Neutrophil count <0.75 x 109/l; haemoglobin levels <7.5 g/dl or 4.65 mmol/l. Lactation.
Lamivudine: NRTI; following phosphorylation, inhibits HIV reverse transcriptase by viral DNA chain termination; cytosine analog
Zidovudine: NRTI; interferes with HIV viral RNA-dependent DNA polymerase (inhibits viral replication); thymidine analog
Renal and hepatic impairment; poor bone marrow reserve prior to treatment; risk of opportunistic infection; patients (especially obese women) with risk factors for or active liver disease. Patients with low body wt should avoid the combined formulation. Separate formulations of lamivudine or zidovudine should not be given at the same time as the combined formulation. If dose adjustment is necessary for either component, separate formulations should be used. Monitor haematological parameters (advanced disease: 2 wkly for 1st 3 mth of treatment, then monthly; early disease: 1-3 mthly), LFTs, mean cell volume, serum creatinine kinase, viral load, CD4 counts and blood lactate levels.
Patient to report any sore throat, nausea, vomiting, unexplained bruising or bleeding. Maintain adequate hydration (2-3 L/day) unless fluid restricted. Withdraw treatment if symptomatic hyperlactaemia, metabolic/lactic acidosis, progressive heptomegaly or rapidly elevating aminotransferase levels occur. Cases of lactic acidosis and hepatic steatosis syndrome have been reported in pregnancy. Monitor hepatic enzymes and electrolytes regularly during 3rd trimester.
Lactation: not recommended
>10%
Headache (35%),Nausea (33%),Malaise & fatigue (27%),Cough (18%),Diarrhea (18%),Vomiting (13%),Musculoskeletal pain (12%),Neuropathy (12%),Insomnia & other sleep disorders (11%)
1-10%
Anorexia &/or decreased appetite (10%),Dizziness (10%),Fever or chills (10%),Abdominal pain (9%),Depressive disorders (9%),Skin rashes (9%),Myalgia (8%),Neutropenia (7.2% ),Abdominal cramps (6%),Arthralgia (5%),Dyspepsia (5%),Anemia (2.9% )
Frequency Not Defined (serious)
Erythema multiforme,Stevens-Johnson syndrome,Lactic acidosis,Pancreatitis,Hepatomegaly (Severe),Steatosis of liver (Severe),Anaphylaxis,Immune hypersensitivity reaction,Rhabdomyolysis
Potentially Fatal: Lactic acidosis associated with liver failure and pancreatitis (normally after several mth of treatment); haematological toxicity (eg neutropenia and severe anaemia).
Zidovudine: acyclovir and valacyclovir may increase CNS depression. Increased risk of haematologic toxicity with ganciclovir, valganciclovir, dapsone, doxorubicin, vincristine and vinblastine. Doxorubicin may reduce phophorylation; fluconazole may increase levels/effects; increased risk of hepatic decompensation or haematologic toxicities with interferon-? and ribavirin (also increases risk of pancreatitis and lactic acidosis). Methadone may increase effects/levels. Increased risk of myalgia, malaise and/or fever, maculopapular rash and effects/levels with probenecid. Stavudine may decrease antiviral activity; valproic acid may increase plasma levels (AUC increased by 80%).
Lamivudine: Increased risk of hepatic decompensation or haematologic toxicities with interferon-? and ribavirin (also increases risk of mitochondrial toxicity, pancreatitis and lactic acidosis). Ganciclovir and valganciclovir may increase effects and toxicity; sulfamethoxazole/trimethoprim may increase AUC and decrease clearance (increasing levels and effects).
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