Eclamag

Introduction
Eclamag is a medicine used in the treatment of decreased magnesium levels in blood. It is also used for treatment of seizures in pregnant women who have high blood pressure. It widens the blood vessels in the brain and improves the blood supply to the nerve cells. Eclamag is generally administered by a healthcare professional in a hospital or clinical setting. You should not self-administer this medicine at home. Using of Eclamag may cause redness, pain, and swelling at the site of injection. If these side effects persist or worsen, inform your doctor.
Uses of Eclamag
Seizures in pregnant women with high blood pressure
Decreased magnesium levels in blood
Side effects of Eclamag
Common
Injection site reactions (pain, swelling, redness)
How to use Eclamag
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Eclamag works
Eclamag controls seizures and high blood pressure in pregnant women by widening the blood vessels in the brain and improving the blood supply to the nerve cells. It also treats low levels of magnesium in the blood.
What if you forget to take Eclamag?
If you miss a dose of Eclamag, please consult your doctor.
Quick Tips
If you suffer from bleeding disorder, heart block, kidney problems, or breathing problems.
If you are pregnant or breast-feeding.
If you are taking medicines acting on nervous system, for heart problems, for high blood pressure.
If you are going to be given an anesthetic.
Brief Description
Indication
Eclampsia, Cerebral palsy, Hypomagnesemia, Torsades de pointes, Barium poisoning
Adult Dose
Adult: IV Hypomagnesaemia Symptomatic deficiency: 1-2 g over 5-60 mins, then maintain at 0.5-1 g/hr if needed. Severe: 1-2 g/hr for 3-6 hr, then 0.5-1 g/hr as needed to correct deficiency. Torsades de pointes W/ pulses: Loading dose: 1-2 g over 5-60 mins, then maintain at 0.5-1 g/hr as needed. Pulseless: 1-2 g over 5-20 mins. Barium poisoning 1-2 g. Cerebral oedema 2.5 g. Eclampsia Loading dose: 4-5 g over 10-15 mins, followed by either a continuous infusion of 1 g/hr or deep IM doses of 4-5 g into alternate buttocks 4 hrly. If seizure recurs, an additional IV dose of 2-4 g may be given. Not to exceed 30-40 g/24 hr. IM Hypomagnesaemia Mild deficiency: 1 g 6 hrly for 4 doses. Severe deficiency: Up to 250 mg/kg w/in 4 hr.

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Contraindication
Parenteral: Heart block, severe renal impairment, myocardial damage.
Mode of Action
Magnesium sulfate decreases levels of acetylcholine in motor nerve terminals. It also acts on the myocardium by decreasing the rate of SA node impulse formation and prolonging the conduction time.
Precaution
Renal impairment, myasthaenia gravis, digitalised patients; pregnancy. Monitor serum-magnesium concentrations.
Side Effect
Hypermagnesaemia characterised by nausea, vomiting, flushing, thirst, hypotension, drowsiness, confusion, slurred speech, double vision, bradycardia, muscle weakness. Hypocalcaemia; paralytic ileus.
Interaction
Enhances neuromuscular blockers, digitalis glycosides.