Medicine Overview of Ertinib 150mg Tablet
Ertinib 150 is used in the treatment of non-small cell lung cancer and pancreatic cancer.
Ertinib 150 should be taken on an empty stomach or should be taken one hour before or 2 hour after meal. You should continue to take it as long as your doctor advises it. The duration of treatment varies according to your needs and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, vomiting, fatigue, rash, and weight loss. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. It makes you sensitive towards sunlight, hence wear protective clothing or use sunscreen while going out. In case you develop ulceration in mouth, changes in your vision, or breathing difficulties than it is better to inform the doctor. Your doctor may advise for regular monitoring of liver function while you are taking this medicine.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. It is advised to quit smoking while taking this medicine as it can affect the working of the medicine. If you have to take an antacid or any other medicine, take it at a gap of at least 2 hours after taking the cancer medicine.
- Non-small cell lung cancer
- Pancreatic cancer
- Abdominal pain
- Bone pain
- Breathlessness
- Constipation
- Cough
- Diarrhea
- Fatigue
- Fever
- Infection
- Muscle pain
- Nausea
- Rash
- Stomatitis (Inflammation of the mouth)
- Vomiting
- Weight loss
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Ertinib 150 helps treat non-small cell lung cancer that is locally advanced, or has spread to other areas of the body.
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It should be taken 1 hour before or 2 hours after the meal.
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Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn’t stop or if you find blood in your stools.
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Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
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It makes your skin sensitive towards sunlight. Apply sunscreen or wear protective clothing while going out.
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It is advisable to avoid smoking while taking this medicine, as it makes the drug ineffective and requires dose adjustment.
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Do not take it with medication lowering the stomach acid (such as antacids, H2 blockers including ranitidine), as it may affect the working of medicine.
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Inform your doctor if you develop ulceration in your mouth, changes in your vision or if you experience a worsening cough, shortness of breath, or breathing difficulties while taking this medicine.
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Your doctor may want you to have regular blood tests to monitor your liver function while you are having treatment with this medicine.
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Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
Oral
Locally advanced or metastatic non-small cell lung carcinoma
Adult: 150 mg once daily until disease progression or unacceptable toxicity. Reduce dose in decrements of 50 mg when necessary.
Locally advanced, unresectable or metastatic pancreatic cancer
Adult: As 1st-line treatment with gemcitabine: 100 mg once daily, reduce dose in decrements of 50 mg when necessary.
Safety and efficacy not established
Pregnancy and lactation. Interrupt Erlotinib therapy if patient develops unexplained pulmonary symptoms e.g. dyspnoea, cough, fever; discontinue therapy if interstitial lung disease is diagnosed. Monitor liver functions periodically; extreme caution is needed if total bilirubin is 3x >ULN; close monitoring is required in patients with hepatic impairment. Interrupt/discontinue therapy if severe changes in liver functions (doubling of total bilirubin and/or tripling of transaminases) occur. Interrupt therapy in the event of dehydration especially in patients with predisposing factors to renal failure.
Monitor renal function and serum electrolytes in patients at risk of dehydration. Interrupt or discontinue therapy if patient develops severe bullous and exfoliative skin disorders; eye pain or other acute/worsening ocular disorders. If patient develops GI perforation, discontinue therapy permanently. Patients with CV disorders. Monitor prothrombin time/INR in patients taking warfarin or other coumarin-derivative anticoagulants.
Lactation: excretion in milk unknown/not recommended
>10%
Rash (75-76%),Anorexia (52-69%),Diarrhea (54-55%),Fatigue (52-79%),Nausea (33-40%),Infection (39%),Vomiting (23-25%),Dyspnea (24%),Stomatitis (17-19%),Cough (16%),Pruritus (13%),Conjunctivitis (12%),Dry skin (12%),Keratoconjunctivitis sicca (12%),Abdominal pain (11%)
1-10%
Elevated LFT’s (grade 2),Acne,Paronychia,Weight loss,Pneumonitis pulmonary infiltrate,Pulmonary fibrosis
<1%
Interstitial lung disease-like events
Pregnancy
Based on animal data and its mechanism of action, erlotinib can cause fetal harm when administered to a pregnant woman
Advise females of reproductive potential to use effective contraception during treatment and for 1 month after the last dose
Lactation
No data exist on the presence of erlotinib in human milk, or the effects of erlotinib on the breastfed infant or on milk production
Because of the potential for serious adverse reactions in breastfed infants, including interstitial lung disease, hepatotoxicity, bullous and exfoliative skin disorders, microangiopathic hemolytic anemia, with thrombocytopenia, ocular disorders, and diarrhea
Advise a lactating woman not to breastfeed during treatment and for 2 weeks after the final dose
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