Esotid HP

Introduction
Esotid HP is a combination of two antibiotics and an antacid that effectively treats peptic ulcer disease caused due to H. pylori bacterial infection. It fights against the bacteria to treat the infection. It also relieves acidity and discomfort related to the infection. Esotid HP is a prescription medicine. It is advised to take it as per the prescription. It should be taken in an empty stomach, but it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The treatment must be completed even if you feel better. The common side effects of this medicine are nausea, vomiting, diarrhea, rashes, etc. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help. Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Pregnant or breastfeeding women should also consult with their doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy.

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Uses of Esotid HP
Peptic ulcer disease
Side effects of Esotid HP
Common
Nausea
Diarrhea
Vomiting
Stomach pain
Taste change
Flatulence
Headache
Rash
How to use Esotid HP
Take this medicine in the dose and duration as advised by your doctor. Check the label before use. Esotid HP is to be taken empty stomach.
How Esotid HP works
Esotid HP is a combination of three medicines: Amoxycillin, Clarithromycin and Esomeprazole, which treats stomach/intestinal ulcers caused by the bacteria. Amoxycillin is an antibiotic which works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria in the human body. Clarithromycin is also an antibiotic which stops bacterial growth by preventing the synthesis of essential proteins required by the bacteria to carry out vital functions. Together, they eradicate your infection effectively. Esomeprazole is a proton pump inhibitor (PPI) which reduces the amount of acid in the stomach and relieves acid-related indigestion and heartburn.
Quick Tips
Nexpro HP Combipack is a combination of three medicines which treats stomach/intestinal ulcers by killing the causative bacteria.
Finish the prescribed course of medicine, even if you start to feel better. Stopping it early may make the ulcer harder to treat.
Stop taking Nexpro HP Combipack and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
Brief Description
Indication
Eradication of H. pylori, in active chronic gastric,duodenal and gastric ulcers.
Adult Dose
Oral Each strip contain one Esomeprazole USP 20mg capsule, two Amoxicillin BP 500mg tablets and one Clarithromycin USP 500mg tablet Each strip twice daily for 7-14 days

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Contraindication
Contraindicated in patients with known hypersensitivity to any of its compo-nent.
Mode of Action
Amoxicillin: Inhibits bacterial cell wall synthesis by binding to one or more penicillin binding proteins that in turn inhibit the final transpeptidation step of peptoglycan synthesis in cell wall biosynthesis. Clarithromycin: Inhibits protein synthesis by binding to 50S ribosomal subunit causing antibacterial activity. Esomeprazole is a PPI that suppresses gastric acid secretion by inhibiting H+/K+ ATPase in the gastric parietal cell.

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Precaution
Serious and occasionally fatal hypersensitivity reactions have been reported in patients on Amoxicillin therapy. These reactions are more apt to occur in indivduals with a history of penicillin hypersensitivity. Clarithromycin should not used in pregnant women except in clinical circumstances where no alternative is appropriate.
Side Effect
Common adverse reactions included diarrhoea and nausea. >10% Clarithromycin GI effects, general (13%) 1-10% Clarithromycin Headache (6%),Rash (children 3%),Abdominal pain (adults 2%, children 3%),Abnormal taste (adults 3-7%),Diarrhea (3-6%),Dyspepsia (2%),Heartburn (adults 2%),GI intolerance (oral-dose related),Nausea (adults 3-6%),Vomiting (adults 1%; children 6%),Decreased WBC, elevated BUN (4%), elevated PT (1%) Esomeprazole >10% Headache (2-11%) 1-10% Flatulence (10%),Indigestion (6%),Nausea (6%),Abdominal pain (1-6%),Diarrhea (2-4%),Xerostomia (3-4%),Dizziness (2-3%),Constipation (2-3%),Somnolence (1-2%),Pruritus (1%) Frequency Not Defined Amoxicillin Headache,Rash,Diarrhea, nausea, vomiting,Anemia,AST/ALT elevation,Acute exanthematous pustulosis,Exfoliative dermatitis Seizure,Insomnia,Hemorrhagic colitis,Toxic epidermal necrolysis,Urticaria,Stevens-Johnson syndrome,Anaphylaxis,Candidiasis (mucocutaneous), pseudomembranous colitis, serum sickness

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Interaction
Esomeprazole is metabolized through the cytochrome P450 system, specially through the CYP3A isozymes. Studies have shown that Esomeprazole does not have clinically significant interactions with other drugs metabolized by the cytochrome P450 system, such as warfarin, antipyrine, indomethacin, ibuprofen, phenytoin, propranolol, prednisolone, diazepam, clarithromycin or terfenadine in healthy subject. Clarithromycin use in patients who are receiving theophylline may be associated with an increase of serum theophylline concentrations. There have been reports of interactions of clarithromycin with carbamazepine, cyclosporine, tactrolimus, hexobarbital, phenytoin, alfetanil, disopyramide, lovastatin, bromocriptine, valproate, terfenadine, cisapride, pimozide & astemizole.

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