Faslodex 250

Introduction
Faslodex 250 is an estrogen blocker. It is used in the treatment of breast cancer in women who have gone through menopause. It works by adjusting the level of estrogen and slow down the growth of cancer cells. Faslodex 250 is given as an injection into the muscles under the supervision of a doctor. It should be taken as doctor your doctor’s advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. The most common side effects of this medicine include injection site reaction, headache, vomiting, allergic reaction, and nausea. If these bother you, or appear serious, let your doctor know. There may be ways of reducing or preventing them. Before taking this medicine, tell your doctor if you ever had kidney or liver disease or had bleeding disorder or had any blood clotting medicine. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are pregnant, planning pregnancy or breastfeeding.

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Uses of Faslodex 250
Breast cancer
Side effects of Faslodex 250
Common
Headache
Vomiting
Weakness
Allergic reaction
Nausea
Injection site reaction
Urinary tract infection
Diarrhea
How to use Faslodex 250
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Faslodex 250 works
Faslodex 250 blocks the action of estrogen on breast cancer cells. This can lower or stop the growth of some breast cancer cells that need estrogen to grow.
What if you forget to take Faslodex 250?
If you miss a dose of Faslodex 250, please consult your doctor.
Quick Tips
Faslodex 250 is used for the treatment of hormone dependent breast cancer.
It should only be taken by women who have undergone menopause and cannot become pregnant.
It is given as a slow injection into the muscles (intramuscular) of your buttock.
Inform your doctor if you have any bleeding disorder, kidney or liver disease or if you are receiving any medicines to prevent blood clots.
Do not take Faslodex 250 if you are pregnant or breastfeeding.
Brief Description
Indication
Metastatic breast cancer, in postmenopausal women w/ oestrogen-receptor positive tumours.
Adult Dose
Intramuscular Metastatic breast cancer in postmenopausal women with oestrogen-receptor positive tumours Adult: 500 mg (250 mg into each buttock) on days 1, 15, and 29, then once monthly thereafter. Moderate (Child-Pugh Class B): 250 mg (into 1 buttock) on days 1, 15, and 29, then once monthly thereafter. Severe: Contraindicated.

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Renal Dose
Renal impairment Negligible amounts of fulvestrant are eliminated in urine In clinical trials, fulvestrant concentrations in women with eCrCl ?30 mL/min were similar to women with normal creatinine

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Contraindication
Pregnancy and lactation.
Mode of Action
Fulvestrant competitively binds to oestrogen receptors, forming a nuclear complex, leading to down-regulation of oestrogen receptor protein levels and inhibition of tumour growth.
Precaution
Patient w/ bleeding diatheses, thrombocytopenia. Admin at dorsogluteal inj site. Mild to moderate hepatic and severe renal (CrCl <30 mL/min) impairment. _ Side Effect >10% Nausea (26%) Asthenia (23%) Pain (19%) Vasodilatation (18%) Pharyngitis (16%) HA (15%) Back pain (14%) Constipation (13%) Vomiting (13%) Abd pain (12%) Diarrhea (12%) Inj site pain (11%) 1-10% Cough (10%) Anorexia (9%) Peripheral edema (9%) Chest pain (7%) Flu-like syndrome (7%) Rash (7%) Depression (6%) Fever (6%) UTI (6%) Anemia (5%) <1% Angioedema Leukopenia Myalgia Thrombosis Osteoporosis _ Interaction Increased risk of bleeding when taken concomitantly w/ anticoagulants.