Flocet

Introduction
Flocet is an antibiotic, used in the treatment of bacterial infections. It is also used in treating infections of the urinary tract, nose, throat, skin and soft tissues and lungs (pneumonia). It cures the infection by stopping the further growth of the causative microorganisms. Flocet should be used in the dose and duration as advised by your doctor. It may be taken with or without food, preferably at a fixed time. Avoid skipping any doses and finish the full course of treatment even if you feel better. Do not take a double dose to make up for a missed dose. Simply take the next dose as planned. You may experience nausea and stomach pain as the side effects of this medicine. These are usually temporary and resolve on their own, but please consult your doctor if they bother you or persist for a longer duration. Diarrhea may also occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools. You should not take this medicine if you are allergic to any of its ingredients. Rarely, some people may have a severe allergic reaction which needs urgent medical attention. Signs of this include rash, swelling of the lips, tongue or face, shortness of breath or breathing problems. Special care should be taken in people with kidney problems while taking this medicine.

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Uses of Flocet
Bacterial infections
Side effects of Flocet
Common
Nausea
Stomach pain
Diarrhea
How to use Flocet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Flocet may be taken with or without food, but it is better to take it at a fixed time.
How Flocet works
Flocet is an antibiotic. It works by stopping the action of a bacterial enzyme called DNA-gyrase. This prevents the bacterial cells from dividing and repairing, thereby killing them.
What if you forget to take Flocet?
If you miss a dose of Flocet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
Your doctor has prescribed Flocet to cure your infection and improve symptoms.
Do not skip any doses and finish the full course of treatment even if you feel better.
Discontinue Flocet and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn’t stop or if you find blood in your stools.
Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations.
Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Brief Description
Indication
Leprosy, chronic bronchitis, Community-acquired pneumonia, Uncomplicated skin infections, anthrax, Legionnaire’s disease, Nongonococcal cervicitis, Urethritis, Uncomplicated cystitis, Complicated UTI, Traveller’s diarrhea, bacterial prostatis, Typhoid fever, Skin and soft tissue infections, Uncomplicated gonorrhea, Pelvic inflammatory disease, Lower respiratory tract infections, Septicaemia

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Administration
May be taken with or without food. Avoid antacids or supplements containing Fe or Znor or dairy products w/in 2 hr before or after ofloxacin. Ensure adequate hydration.

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Adult Dose
Oral Bronchitis Exacerbation, Community Acquired Pneumonia, Skin & Skin Structure Infections Adult: 400 mg bid for 10 days. Uncomplicated gonorrhoea Adult: 400 mg as a single dose. Nongonococcal Cervicitis/Urethritis Adult: 400 mg daily in single or divided doses for 7 days. Uncomplicated Cystitis Adult: 200 mg bid for 3-7 days. Complicated UTIs Adult: 200 mg bid for 10 days. Pelvic inflammatory disease Adult: 400 mg bid for 10-14 days. Prostatitis Adult: Acute or chronic: 200 mg bid for 28 days. Intravenous Complicated urinary tract infections Adult: 200 mg daily by infusion over at least 30 min. Max: 400 mg bid infused over at least 1 hr. Lower respiratory tract infections; Septicaemia Adult: 200 mg bid by infusion over at least 30 min. Max: 400 mg bid infused over at least 1 hr. Skin and soft tissue infections Adult: 400 mg bid infused over at least 1 hr. Hepatic impairment: Severe: Reduce dose. Max: 400 mg daily.

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Child Dose
Not indicated
Renal Dose
Renal impairment: CrCl (ml/min) Dosage Recommendation 20-50 Reduce dose by half 24 hrly following usual initial dose. <20 and patients on haemodialysis or peritoneal dialysis 100 mg 24 hrly following usual initial dose.. _ Contraindication Hypersensitivity to quinolones; pregnancy and lactation; prolongation of the QT interval; uncorrected hypokalaemia. Mode of Action Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair and recombination. It has activity against a wide range of gram-negative and gram-positive microorganisms. Precaution Epilepsy or other predisposition to seizures; known or suspected CNS disorders; renal, hepatic impairment; myasthaenia gravis; superinfection; children <18 yr; exposure to strong sunlight and UV light; ensure adequate hydration; elderly. Lactation: excreted in breast milk, discontinue drug or do not nurse _ Side Effect 1-10% Nausea (3-10%),Headache (1-9%),Insomnia (3-7%),Dizziness (1-5%),Vaginitis (1-5%),Diarrhea (1-4%),Vomiting (1-4%),Appetite decreased (1-3%),Abdominal cramps (1-3%),Abnormal taste (1-3%),Chest pain (1-3%),External genital pruritis in women (1-3%),Fatigue (1-3%),Flatulence (1-3%),GI distress (1-3%),Nervousness (1-3%),Pharyngitis (1-3%),Pyrexia (1-3%),Rash/pruritis (1-3%),Sleep disorders (1-3%),Visual disturbances (1-3%),Xerostomia (1-3%) <1% Prolonged QT interval,Torsades de pointes,Syncope,Vasculitis,Edema,HTN,Palpitations,Vasodilation,Stevens-Johnson syndrome,Toxic epidermal necrolysis,Agranulocytosis,Aplastic anemia,Pancytopenia,Thrombocytopenia,Thrombocytopenic purpura,Acute hepatitis,Hepatic failure,Hepatic necrosiImmune hypersensitivity reaction,Rupture of tendon, Tendinitis,Peripheral neuropathy,Seizure,Acute renal failure,Interstitial nephritis,Renal impairment,Tourette's syndrome,Decrease hearing acuity,Tinnitus Potentially Fatal: Anaphylaxis; rarely seizures. _ Interaction Concomitant use of class IA (e.g. quinidine, procainamide) or class III (e.g. amiodarone, sotalol) antiarrhythmic agents may increase risk of QT interval prolongation. Decreased serum and urine concentrations w/ antacids containing Mg, Al or Ca. Additive antibacterial activity w/ aminoglycosides (e.g. amikacin, tobramycin). Corticosteroids may increase risk of severe tendon disorders. Increased risk of CNS stimulation (e.g. seizures) w/ NSAIDs. Higher and prolonged serum theophylline concentrations and increased risk of theophylline-related adverse effects.