Medicine Overview of Heparon 25000IU/ml Injection
Heparon is an anticoagulant which prevents abnormal clotting of blood. It not only prevents the formation of harmful blood clots in the legs, lungs, and heart but also stops them from growing bigger.
Heparon is administered under the supervision of a doctor. Your doctor will decide how often you should take this medicine. This may change from time to time depending on how well it is working. You should take this medicine regularly to get the most benefit, even if you feel fine. It is preventing future harm. Your doctor may get regular blood tests done to make sure this medicine is working well and monitor the levels of potassium and platelets.
Use of this medicine may increase your risk of bleeding. Let your doctor know immediately if you see pinpoint rash or blood in your vomits, urine, or stool. You should be careful while shaving, cutting nails, using sharp objects, or engaging in contact sports.
You must inform the doctor if you are suffering from any liver or kidney disease. Also, let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it.
- Blood clots
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Notify your doctor if you see blood in your urine or stool or any unusual bleeding from your skin, gums or nose.
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Inform your doctor if you experience rash, itching, swelling of the face, tongue, and throat while you receive this medicine.
IV Preparation
Recommended infusion concentration for most patients is 25,000 units in 500 mL D5W (50 units/mL premixed infusion solution)
IV Administration
IV injection may be given undiluted or diluted in 50-100 mL NS or D5W
Infusion: Dilute in NS, D5W, or other compatible fluid
Continuous IV therapy is preferred because intermittent IV therapy produces a higher incidence of bleeding abnormalities
DVT & Pulmonary Embolism
Prophylaxis
5000 units Subcutaneous(SC) q8-12hr, OR
7500 units SC q12hr
Treatment
80 units/kg IV bolus, THEN continuous infusion of 18 units/kg/hr, OR
5000 units IV bolus, THEN continuous infusion of 1300 units/hr, OR
250 units/kg (alternatively, 17,500 units) SC, THEN 250 units/kg q12hr
Acute Coronary Syndromes
PCI
Without GPIIb/IIIa inhibitor: Initial IV bolus of 70-100 units/kg (target ACT 250-300 sec)
With GPIIb/IIIa inhibitor: Initial IV bolus of 50-70 units/kg (target ACT >200 sec)
STEMI
Patient on fibrinolytics: IV bolus of 60 units/kg (max: 4000 units), THEN 12 units/kg/hr (max 1000 units/hr) as continuous IV infusion
Dose should be adjusted to maintain aPTT of 50-70 sec
Unstable Angina/NSTEMI
Initial IV bolus of 60-70 units/kg (max: 5000 units), THEN initial IV infusion of 12-15 units/kg/hr (max: 1000 units/hr)
Dose should be adjusted to maintain aPTT of 50-70 sec
Anticoagulation
Intermittent IV injection
8000-10,000 units IV initially, THEN 50-70 units/kg (5000-10,000 units) q4-6hr
Continuous IV infusion
5000 units IV injection, followed by continuous IV infusion of 20,000-40,000 units/24 hr
Catheter Patency
Prevention of clot formation within venous and arterial catheters
Use 100 units/mL; instill enough volume to fill lumen of catheter
Venous Thromboembolic Prophylaxis
100-150 units/kg IV once
Venous Thromboembolic Treatment
<1 year
Loading dose of 75 units/kg IV, THEN 28 units/kg/hr IV as initial maintenance dose
>1 year
Loading dose of 75 units/kg IV, THEN 20 units/kg/hr IV as initial maintenance dose
I
ntermittent IV injection
Initially give 50-100 units/kg IV infusion, THEN 100 units/kg IV infusion q4hr as a maintenance dose
Monitor platelet counts. Discontinue treatment if thrombocytopenia occurs. Hypersensitivity, elderly, pregnancy.
Lactation: Not excreted in breast milk; compatible
>10%
Heparin-induced thrombocytopenia, possibly delayed (10-30% )
Frequency Not Defined
Mild pain,Hematoma,Hemorrhage,Local irritation,Erythema,Injection site ulcer (after deep SC injection),Increased liver aminotransferase,Anaphylaxis,Immune hypersensitivity reaction,Osteoporosis (long-term, high-dose use)
Potentially Fatal: Heparin-induced thrombocytopenia with or without thrombosis; bleeding.
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