Hexaxim

Indication
Diphtheria, Tetanus, Pertussis, Hepatitis B in infants
Child Dose
Immunization Diphtheria, tetanus, pertussis, hepatitis B Deep IM inj Primary vaccination 3 doses of 0.5 mL w/in the 1st 6 mth of life at intervals of at least 4 wk. Booster dose: Administer during the 2nd yr of life.

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Contraindication
Previous encephalopathy after pertussis vaccine; acute severe febrie illness.Hypersensitivity to any component of the vaccine. Childn w/ history of encephalopathy of unknown etiology occurring w/in 7 days following previous vaccination. Do not administer IV.
Mode of Action
Vaccine is used for the active immunisation of diphtheria, tetanus and pertussis in children from 6 wk to 6 yr of age. Production of specific antibodies to tetanus, diphtheria, and pertusis (active immunity). Conveys active immunity via stimulation of production of endogenously produced antibodies
Precaution
Previous reaction to DTP vaccine; family history of convulsions, SIDS; bleeding dis­orders; immunosuppression /deficiency; preg­nancy, lactation. Postpone vaccination in patients w/ acute severe febrile illness. Should be administered SC in patients w/ thrombocytopenia or bleeding disorders. Syncope, risk of apnea. Temp >40°C, persistent crying lasting >3 hr & collapse or shock-like state w/in 48 hrs; convulsions w/ or w/o fever w/in 3 days. High incidence of pertussis. Childn w/ progressive neurological disorders including infantile spasms, uncontrolled epilepsy or progressive encephalopathy. Consider potential risk of apnea & need for resp monitoring for 48-72 hr to very premature infants (>28 wk of gestation) particularly those w/ previous history of resp immaturity. Lactation: Not indicated for women of childbearing age

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Side Effect
>10% Irritability/fussiness (61-65%),Drowsiness (41-57%),Fever (28-39%),Loss of appetite (26-31%),Swelling (17-29%) 1-10% Fever (≤1%) <1% Anorexia,Apnea,Erythema,Decreased consciousness,Diarrhea,Hypotonia,Encephalitis,Brachial neuritis,Erythema,Peripheral neuropathy,Cough,Lethargy,Limb pain,Liver function test abnormalities,Rash,Restlessness _ Pregnancy Category Note Pregnancy Category: C Lactation: Not indicated for women of childbearing age _