Medicine Overview of Histin 5mg/5ml Syrup
Histin used in the treatment of various allergic conditions like runny nose, sneezing, congestion, itching and watery eyes. It also treats nausea, vomiting and insomnia (difficulty in sleeping) in adults and used as a sedative (sleep causing) in children (for 5 years and above).
Histin should be taken with or without food, but take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. In case, you have missed any doses than it is better to take the next dose as soon as you remember it. However, you should never take a double dose. you must inform your doctor if symptoms does not get improve within 7 days of treatment.
The most common side effects of this medicine include dry mouth, blur vision, headache, and feeling dizzy. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It makes skin more sensitive towards sunlight. use sunscreen or wear protective clothing before going out.
Before taking this medicine, let your doctor know if you have glaucoma or have asthma issues or have high blood pressure. Inform your doctor if you are pregnant, or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Generally, it is advised to avoid alcohol while on treatment.
- Nausea
- Vomiting
- Dryness in mouth
- Blurred vision
- Headache
- Dizziness
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Histin helps treat nausea and vomiting.
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It may also be used for the short-term treatment of sleeping difficulties (insomnia) in adults and as a sedative in children.
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Use caution while driving or doing anything that requires concentration as Histin can cause dizziness and sleepiness.
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Do not drink alcohol while taking this medication as it may cause increased sleepiness.
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It may make your skin more sensitive to sunlight. Avoid exposing your skin to strong sunlight, use a sunscreen lotion or make sure your skin is protected with clothing.
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Do not take it for longer than 7 days. If your symptoms worsen or do not improve after 7 days, talk to your doctor.
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Stop taking it at least three days before taking an allergy test as it can affect the test results.
Oral
Allergic conditions
Adult: As promethazine HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.
Prophylaxis of motion sickness
Adult: As promethazine HCl: 20 mg or 25 mg the night before travelling, followed by a similar dose the following morning if necessary. As promethazine teoclate: 25 mg given on the night or 1-2 hr before travelling.
Short-term management of insomnia
Adult: As promethazine HCl: 20-50 mg at night.
Parenteral
Allergic conditions; Sedation
Adult: As promethazine HCl: 25-50 mg, by deep IM, IV inj or IV infusion at a rate of not more than 25 mg/min. Max: 100 mg.
Nausea and vomiting
Adult: As promethazine HCl: 12.5-25 mg, repeated at intervals of not less than 4 hr. Max: 100 mg daily.
Oral
Allergic conditions
Child: As promethazine HCl:
2-5 yr 5-15 mg daily in 1 or 2 divided doses;
>5-10 yr 10-25 mg daily in 1 or 2 divided doses.
Prophylaxis of motion sickness
Child: As promethazine HCl:
2-5 yr 5 mg;
>5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary.
Short-term management of insomnia
Child: As promethazine HCl:
2-5 yr 15-20 mg;
>5-10 yr 20-25 mg.
Parenteral
Allergic conditions; Sedation
Child: As promethazine HCl: 5-10 yr 6.25-12.5 mg by deep IM.
Patients in coma or suffering from CNS depression of any cause. Childn <2 yr. SC and intra-arterial admin. Concurrent use w/ or w/in 14 days of MAOI use.
Patient w/ asthma, bronchitis or bronchiectasis; severe coronary artery disease, narrow-angle glaucoma, epilepsy, bladder neck or pyloro-duodenal obstruction, Reye’s syndrome, bone marrow depression, Hepatic and renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause marked drowsiness, if affected, do not drive or operate machinery. Avoid prolonged exposure to sunlight. Monitoring Parameters Monitor mental status; signs and symptoms of tissue injury (IV inj).
Lactation: Not known whether drug crosses into breast milk; discontinue drug, or do not nurse
Neuroleptic Malignant Syndrome (NMS); CV effects (e.g. bradycardia, tachycardia, transient HTN, hypotension; jaundice, blood dyscrasias, extrapyramidal effects; IV inj: Severe tissue injury (e.g. gangrene), pain and burning, paralysis, thrombophlebitis, severe spasm of distal vessels, necrosis. Sedation, Confusion, Disorientation, Blurred vision, Hallucinations, Dystonias, Catatonic states, Euphoria, Excitation, Impotence, Urinary retention
Potentially Fatal: Resp depression and apnoea esp in childn.
Masks ototoxicity of aminoglycoside antibiotics. May enhance the sedative effects of CNS depressants like alcohol, hypnotics, barbiturates and opioids.
Potentially Fatal: Ventricular arrhythmias when used with drugs that prolong QT interval. Increased risk of extrapyramydal effects w/ MAOIs.
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