Imovane 7.5

Introduction
Imovane 7.5 is a prescription medicine used for short term treatment of insomnia. It reduces sleep onset time and frequent awakening at night. This medicine improves sleep maintenance and therefore ensures sound sleep. Imovane 7.5 is never used for long term treatment of insomnia, because of its high habit forming potential. It should be taken on an empty stomach, preferably just before going to bed. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it is habit forming. Do not stop taking it suddenly without talking to your doctor as it may worsen your symptoms. Some common side effects of this medicine include metallic taste, drowsiness, sleepiness, and dry mouth. However, these are temporary and resolve on their own after some time. Please consult your doctor if these bother you or do not away. Imovane 7.5 also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you and do not take alcohol with it as it may worsen the dizziness. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, hallucinations or suicidal thoughts while taking this medicine. Before taking Imovane 7.5, inform your doctor about all other medicines that you are taking, so that your doctor can advise if taking this medicine is right for you. Consult your doctor before taking this medicine if you are suffering from any liver or kidney problems. You should avoid smoking and alcohol while using this medicine. Pregnant and breastfeeding mothers should not use this medicine. However, if the need arises, please consult your doctor before using it.

_
Uses of Imovane 7.5
Insomnia
Side effects of Imovane 7.5
Common
Metallic taste
How to use Imovane 7.5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Imovane 7.5 is to be taken empty stomach.
How Imovane 7.5 works
Imovane 7.5 is a nonbenzodiazepine hypnotic. It has hypnotic and anxiolytic properties. It works by regulating the GABA receptor, thus relaxes the nerves and brain. This is how it helps you to fall asleep.
What if you forget to take Imovane 7.5?
If you miss a dose of Imovane 7.5, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
Your doctor has prescribed Imovane 7.5 to help you fall asleep faster and sleep for longer.
It is best taken without food as a high-fat meal can reduce its absorption and effect.
Take it 30 to 45 minutes before bedtime and only when you have time to sleep for at least 7 hours.
It makes you feel dizzy next morning. Don’t drive or do anything requiring concentration until you know how it affects you.
It does not affect total sleep time. However, it reduces sleep onset time and frequent awakening at night.
Never share your medication with any other person who also has a sleep problem.
It may cause a bitter taste in your mouth or a dry mouth. Try sipping water and inform your doctor if it bothers you.
Inform your doctor if your sleep doesn’t improve after 7 to 10 days of treatment.
Stop taking medication and inform your doctor If you experience sleep driving or memory loss.
Do not stop taking medication suddenly as it may lead to anxiety, mood changes, and restlessness.
Brief Description
Indication
Insomnia
Administration
May be taken with or without food.
Adult Dose
Oral Short-term management of insomnia Adult: 7.5 mg at bedtime. Elderly: Initially, 3.75 mg at bedtime. Hepatic impairment: Mild to moderate: Initially 3.75 mg at bedtime. Severe: Contraindicated.

_
Child Dose
Child: Not recommended.
Renal Dose
Renal impairment: Initiate at 3.75 mg at bedtime.
Contraindication
Myasthenia gravis; respiratory failure; severe sleep apnoea syndrome; severe hepatic impairment; pregnancy, lactation.
Mode of Action
Zopiclone is a cyclopyrrolone derivative with hypnotic and sedative actions, anticonvulsant and muscle relaxant properties similar to benzodiazepines. It binds to a site in the GABA-A-benzodiazepine-chloride channel macromolecular-receptor complex which is different from that of the benzodiazepine binding site.
Precaution
Hepatic and renal insufficiency; elderly; psychiatric disorders; history of drug abuse. May impair ability to drive or operate machinery. Limit treatment duration to <4 wk to minimise risk of dependence and tolerance. Avoid abrupt discontinuation of therapy. _ Side Effect Metallic or bitter aftertaste; irritability, confusion, depressed mood, aggressiveness, incoordination, anterograde amnesia, mild increase in LFTs, drowsiness, lightheadedness, nausea, vomiting, urticaria, rashes. Interaction Reduced hypnotic effect with phenytoin and carbamazepine. Increased drowsiness and incoordination with TCAs. Increased CNS depressant effect with alcohol and other CNS depressants. Decreased zopiclone concentration with rifampicin. Possible increase in zopiclone concentration with CYP3A4 inhibitors e.g. erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir.