Ketofun

Tablet - 200mg

1 Tablet

Description

Medicine Overview of Ketofun 200mg Tablet

Introduction

Ketofun belongs to a group of medicines called antifungals. It is used to treat fungal infections of the skin. It works by killing the fungus that causes infections such as athlete’s foot, thrush and ringworm.

Ketofun should be used in the dose and duration as prescribed by your doctor. This medicine should be used regularly to get the maximum benefit from it. Do not use more than you need, it will not clear your condition faster and may only increase the side effects. Skin infections will usually get better after 2 to 4 weeks. Do not use the medicine for longer than your doctor has told you to and let him or her know if your condition does not improve after 2 to 4 weeks of treatment. If you have Athlete’s foot, wash your socks or tights thoroughly and change your shoes daily if possible.

The most common side effects of using this medicine include a burning sensation and irritation, dryness, peeling or blistering of the skin. Occasionally it can cause thinning of your hair. These are not usually serious, but you should call your doctor if you think you might have a severe allergic reaction. Signs of this include rash, swelling of the lips, throat or face, swallowing or breathing problems. Get emergency help if this happens. Avoid direct contact of the medicine with your eyes. In the case of direct contact, wash your eyes with water and seek immediate medical attention.

It is not likely that other medicines you take by mouth or injection will affect the way this medicine works, but talk to your doctor before using it if you have recently used another medicine that contains a steroid or had an allergic reaction to another antifungal medicine. For pregnant or breastfeeding women, this cream should only be used if it is clearly needed.

Uses of Ketofun

Fungal skin infections

Side effects of Ketofun

Common

Application site burning
Skin peeling

How to use Ketofun

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Ketofun works

Ketofun is an antifungal medication. It kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection.

What if you forget to take Ketofun?

If you miss a dose of Ketofun, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

KZ Cream helps treat skin infections caused by many different types of fungi.

Few healthy tips for Athlete’s Foot:

Apply an amount sufficient to cover the affected area and 1 inch of the immediate surrounding skin.

Finish the full course of treatment even if you feel better.

Avoid getting it in the eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water.

Inform your doctor if the infection has not cleared up after 4 weeks of treatment.

Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Brief Description

Indication

Candidiasis, Fungal infections, Pityriasis versicolor, Seborrhoeic dermatitis

Administration

Should be taken with food.

Adult Dose

Oral
Fungal infections
Adult: 200 mg once daily; may increase to 400 mg once daily if clinical response is insufficient. Continue treatment until symptoms have cleared and cultures have become negative.

Chronic vag candidiasis
400 mg once daily for 5 days.

Elderly: No dosage adjustment needed.

Hepatic impairment: Contraindicated.

Child Dose

Oral
Fungal infections
Child: >2 yr 3.3-6.6 mg/kg/day once daily.
Treatment duration: 1-2 wk for candidiasis; at least 4 wk in recalcitrant dermatophyte infections and up to 6 mth for other systemic mycoses.

Renal Dose

Renal impairment: No dosage adjustment needed.

Contraindication

Hypersensitivity; preexisting liver disease, porphyria. Concurrent use with cisapride, terfenadine or astemizole.

Mode of Action

Ketoconazole interferes w/ biosynthesis of triglycerides and phopholipids by blocking fungal CYP450, thus altering cell membrane permeability in susceptible fungi. It also inhibits other fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide.

Precaution

Hepatic impairment; monitor liver function regularly. Pregnancy, lactation. Predisposition to adrenocortical insufficiency. Discontinue treatment if there is persistent or worsening of liver enzyme elevation.

Side Effect

1-10%
Nausea and vomiting (3-10%),Pruritus (2%),Abdominal pain (1%)

<1%
Alopecia,Headache,Dizziness,Hyperlipidemia,Somnolence,Fever,Chills,Bulging fontanelles,Depression,Gynecomastia,Diarrhea,Impotence,Thrombocytopenia,Leukopenia,Hemolytic anemia,Erythema multiforme,Orthostatic hypotension,Jaundice,Dyspepsia,Dysgeusia,Hepatotoxicity,Decreased platelet count,Xeroderma,Photophobia

Potentially Fatal: Hepatotoxicity.

Interaction

Reduced absorption w/ antimuscarinics, antacids, H2-blockers, PPIs, sucralfate. Reduced plasma concentrations w/ rifampicin, isoniazid, efavirenz, nevirapine, phenytoin. May also reduce concentrations of isoniazid and rifampicin. May reduce efficacy of oral contraceptives. May increase serum levels of CYP3A4 substrates e.g. digoxin, oral anticoagulants, sildenafil, tacrolimus.

Potentially Fatal: May potentiate and prolong sedative and hypnotic effects of midazolam and triazolam. Increased plasma levels and prolonged QT intervals of astemizole, cisapride, dofetilide, pimozide, quinidine and terfenadine which may lead to torsade de pointes. Increased risk of myopathy w/ HMG-CoA reductase inhibitors (e.g. lovastatin, simvastatin). Markedly increased plasma levels of nisoldipine. Increased risk of hyperkalaemia and hypotension w/ eplerenone. Increased risk of vasospasm potentially leading to cerebral ischaemia w/ ergot alkaloids (e.g. ergotamine, dihydroergotamine).