Ludiomil 25

Indication
Depression
Administration
May be taken with or without food.
Adult Dose
Oral Depression Adult: As hydrochloride: 25-75 mg daily in 3 divided doses, gradually increased in 25 mg increments at 1-2 wk intervals to 150 mg/day if necessary. Up to 225 mg/day in severely depressed patients. Elderly: Initial: 25 mg daily. May increase slowly according to response to 50-75 mg daily if needed.

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Child Dose
Safety and effecay not established
Contraindication
Preexisting CV insufficiency; epilepsy or lowered seizure threshold.
Mode of Action
Maprotiline is a tetracyclic antidepressant pharmacologically similar to the tricyclic antidepressants. It’s antidepressant effects appear to be due principally to inhibition of the re-uptake of noradrenaline at the neuronal membrane.
Precaution
Urinary retention, prostatic hyperplasia, chronic constipation, untreated angle-closure glaucoma; hyperthyroidism; risk of suicide; may precipitate mania or psychotic symptoms; withdraw gradually; may impair ability to operate machinery. Pregnancy and lactation; elderly. Lactation: avoid during breastfeeding

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Side Effect
Common Fatigue,Sedation,Lethargy,Weakness,Constipation,Dry mouth,Blurred vision Less Common Agitation,Anxiety,Headache,Insomnia,Nausea,Vomiting,Sweating Infrequent Orthostatic hypotension, ECG changes, tachycardia Confusion, EPS, dizziness, paresthesia, tinnitus Rash,Incr LFTs,Sexual dysfunction Rare Seizure,Agranulocytosis,Thrombocytopenia,Eosinophilia,Leukopenia,SIADH Potentially Fatal: Seizures

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Interaction
MAOIs. Increase in sedative effect with alcohol. Increased effect of antidiabetics. Maprotiline concentrations and toxicity increased by propranolol, risperidone. Risk of seizures increased with phenothiazines.