Macrocin-T

Introduction
Macrocin-T is an antibiotic used to treat acne (pimples) and some bacterial skin infections. It helps to reduce the number of pimples. This medicine stops the bacteria from growing, which helps to resolve your symptoms. Macrocin-T is meant for external use only. It should be applied only to the affected area of the skin as per the dosage and schedule prescribed by your doctor. In order to get the most benefit, apply it regularly and preferably at a fixed time each day. Do not use larger amounts or apply it more often or for a longer duration than directed. This will only increase the risk of side effects. You may have to use it for a long time before your acne starts to improve. Be patient and keep using it every day. This medicine is generally safe to use with minimal side effects such as peeling of skin, redness, dry skin, irritation, itching, stinging and burning sensation, etc. Consult your doctor if these persist or if your condition does not improve. Avoid any contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get the medicine in these areas. Before using it, inform your doctor if you have any previous history of allergy to it or any other medicine. Pregnant or breastfeeding women should consult their doctor before using it.

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Uses of Macrocin-T
Acne
How to use Macrocin-T
Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use.
How Macrocin-T works
Macrocin-T is an antibiotic which stops the growth of acne-causing bacteria on the skin. It does so by preventing synthesis of essential proteins required by these bacteria to carry out vital functions.
What if you forget to take Macrocin-T?
If you miss a dose of Macrocin-T, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
You have been prescribed Macrocin-T for the treatment of severe acne.
You may have to use it for a long time before your acne starts to improve. Be patient and keep using it every day.
Apply it as a thin layer on to clean, dry, unbroken skin affected by acne.
Wash your skin with a mild cleanser and pat it dry before applying Macrocin-T.
It may cause minor burning, stinging, or irritation when applied. Inform your doctor if this does not go away.
Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get the cream in these areas.
If you think the area of skin you are treating has become more irritated and infected, you should stop using Macrocin-T and consult your doctor.
Brief Description
Indication
Acne
Administration
Apply to affected areas after skin is thoroughly washed and patted dry
Adult Dose
Topical/Cutaneous Acne Adult: Apply onto affected areas 1-2 times daily. Discontinue treatment if condition worsens or if there is no improvement after 6-8 wk of continuous usage. Max duration: 6 mth.

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Child Dose
Safety and efficacy not established
Contraindication
Hypersensitivity; porphyria; hepatic impairment; pregnancy.
Mode of Action
Erythromycin inhibits protein synthesis by irreversibly binding to the 50S ribosomal subunit thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.
Precaution
Increased risk of cholestatic hepatitis when treatment is >10 days or in patients with previous history of erythromycin usage. History of hepatic disorders; arrhythmias; prolonged QT interval; lactation. Monitor liver function. Avoid estolate in liver impairment. Caution when using lactobionate in patients with severe renal impairment. May aggravate muscle weakness in patients with myasthenia gravis. Lactation: Unknown if excreted in breast milk; use with caution

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Side Effect
Contact sensitization,Dryness,Erythema,Skin irritation,Skin tenderness Potentially Fatal: Hepatotoxicity, cholestatic jaundice; raised serum transaminases; eosinophilia.

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Pregnancy Category Note
Pregnancy Category: B Lactation: Unknown if excreted in breast milk; use with caution

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Interaction
Rhabdomyolysis w/ or w/o renal impairment w/ HMG-CoA reductase inhibitors (e.g. simvastatin). Increased risk of colchicine toxicity. Increased sedation w/ triazolobenzodiazepines and related benzodiazepines (e.g. alprazolam, midazolam). Theophylline may decrease and cimetidine may increase erythromycin concentration. Hypotension, bradyarrhythmia and lactic acidosis w/ Ca channel blockers (e.g. verapamil, amlodipine, diltiazem). Increased systemic exposure of sildenafil. Increased or prolonged adverse effects w/ ciclosporin, carbamazepine, tacrolimus, alfentanil, disopyramide, rifabutin, quinidine, methylprednisolone, cilostazol, vinblastine and bromocriptine. Increased risk of digoxin toxicity. Increased bleeding w/ oral anticoagulants. Potentially Fatal: QT prolongation, cardiac arrhythmias, ventricular tachycardia, ventricular fibrillation, torsades de pointes w/ cisapride, pimozide, astemizole or terfenadine. Acute ergot toxicity w/ ergotamine and dihydroergotamine.

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