Medicine Overview of Maxiflox 400mg Tablet
Maxiflox is an antibiotic, used in the treatment of bacterial infections of the eye. It relieves the symptoms of the infection by stopping the further growth of the causative microorganisms.
Maxiflox is for external use only. Take it in the dose and duration as advised by your doctor. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid. Avoid skipping any doses and finish the full course of treatment even if you feel better.
It may cause eye discomfort, dry eyes and burning sensation in the eyes immediately following application. However, these side effects are temporary and usually subside on their own. Inform your doctor if they persist for a longer duration. It may cause short term blurring of vision when first used. Use caution before driving or using machines. Do not wear contact lenses while using it.
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- Bacterial eye infections
- Eye discomfort
- Dry eye
- Burning sensation
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You have been prescribed Maxiflox for the treatment of bacterial infections of the eye.
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Do not skip any doses and finish the full course of treatment even if you feel better.
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Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the medication.
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Do not touch the tip to any surface, or to your eye, to avoid contamination.
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Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
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It may cause short term blurring of vision when first used. Use caution before driving or using machines.
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Do not wear contact lenses until your infection clears up.
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Make sure to use within 4 weeks of opening the medication.
Oral
The dose of Moxifloxacin is 400 mg once every 24 hours. The duration of therapy depends on the type of infection as described bellow
Acute Bacterial Sinusitis
400 mg is given once daily for 10 days.
Acute Bacterial Exacerbation of Chronic Bronchitis
400 mg is given once daily for 5 days.
Community Acquired Pneumonia
400 mg is given once daily for 7-14 days.
Uncomplicated Skin & Skin Structure infections
400 mg is given once daily for 7 days.
Complicated Skin & Skin Structure infections
400 mg is given once daily for 7-21 days.
Complicated Intra-Abdominal infections
400 mg is given once daily for 5-14 days.
Typhoid Fever
400 mg is given once daily for 10-14 days.
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<18 years: Safety and efficacy not established
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Maintain adequate fluid intake; Patient w/ previous tendon disorders (e.g. rheumatoid arthritis), significant bradycardia or acute myocardial ischaemia, heart failure w/ reduced LVEF, known history of symptomatic arrhythmias, known or suspected CNS disorders (e.g. severe cerebral arteriosclerosis, epilepsy) or other risk factors that predispose to seizures; diabetes. Kidney, heart or lung transplant recipients. Hepatic impairment. Pregnancy and lactation.
Patient Counselling This drug may cause dizziness and lightheadedness, if affected do not drive or operate machinery. Rest and refrain from doing strenuous physical activity as it may increase risk of tendon rupture. Avoid exposure to sunlight or artificial UV light (e.g. tanning beds, UVA/UVB treatment) and use protective measures (e.g. sunscreen, wear loose-fitting clothes) if staying outdoors is necessary during therapy. Monitoring Parameters Monitor WBC and signs of infection.
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1-10%
Nausea (7%),Diarrhea (6%),Dizziness (3%),Decreased amylase (2%),Decreased basophils, eosinophils, hemoglobin, prothrombin time, red blood cells, neutrophils (2%),Decreased serum glucose (2%),Increased serum chloride (2%),Increased serum ionized calcium (2%),Immune hypersensitivity reaction (0.1-2%),Prolonged QT interval (0.1-2%)
<1%
Acute renal failure,Agranulocytosis,Anaphylactoid reaction,Aplastic anemia,Extrinsic allergic alveolitis,Hemolytic anemia,Hepatic failure,Hepatic necrosis,Hepatitis,Pancytopenia,Seizure,Serum sickness due to drug,Stevens-Johnson syndrome,Tendon rupture, tendinitis,Thrombocytopenia,Torsades de pointes,Toxic epidermal necrolysis
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Additive effect on QT interval prolongation w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents). Decreased absorption and bioavailability w/ Al- or Mg-containing antacids, or Fe or Zn preparations. Concomitant use of corticosteroids increases the risk of severe tendon disorders esp in elderly (>60 yr). Decreased absorption w/ sucralfate or didanosine.
Potentially Fatal: Concurrent use of class Ia (e.g. quinidine, procainamide) or III (e.g. amiodarone, sotalol) antiarrhythmic drugs or w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents) may cause additive effect on QT interval prolongation.
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