Mebolin

Indication
Allergic conditions
Administration
Should be taken with food. Take during or shortly after meals.
Adult Dose
Oral Allergic conditions Adult: 100-300 mg/day.

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Child Dose
Oral Allergic conditions Child: <2 yr: 50-100 mg/day; 2-5 yr: 50-150 mg/day; 5-10 yr: 100-200 mg/day; >10 yr: 100-300 mg/day.

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Contraindication
Premature infants and neonates. Acute asthmatic attack.
Mode of Action
Mebhydrolin is an ethylenediamine derivative antihistamine with antimuscarinic and sedative properties.
Precaution
Closed-angle glaucoma; urinary retention, prostatic hyperplasia or pyloroduodenal obstruction; epilepsy. Elderly. Pregnancy. May impair ability to drive or operate machinery.
Side Effect
CNS depression; paradoxical stimulation (high doses, children or elderly); headache, psychomotor impairment; dry mouth, thickened respiratory tract secretions, blurred vision; urinary difficulty or retention, constipation, increased gastric reflux; nausea, vomiting, diarrhoea, epigastric pain. Rarely, blood disorders. Convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, sleep disturbances, depression, confusion, tinnitus, hypotension, hair loss. Potentially Fatal: Anaphylaxis.

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Interaction
Enhanced sedation with alcohol or other CNS depressants. Additive antimuscarinic effects with MAOIs, atropine, TCAs. May mask warning symptoms caused by ototoxic agents e.g. aminoglycoside antibiotics.