Medicine Overview of Mecab 750mg tablet
Mecab 750 is a muscle relaxer. It provides relief from the discomfort associated with acute, painful musculoskeletal conditions such as rigidity, tension, stiffness, and muscle spasms.
Mecab 750 is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. It may be only part of a treatment program that includes other medicines and therapies.
The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), headache, drowsiness, fatigue, vomiting, constipation, dry mouth, and sweating. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.
Before using it, you should let your doctor know if you have problems with your heart, liver, or kidneys. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.
If you are pregnant or breastfeeding, it is important to ask the advice of your doctor before taking this medicine. Your doctor may also regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.
- Muscle relaxation
- Sleepiness
- Dryness in mouth
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Mecab 750 provides relief from rigidity, tension and stiffness in muscles (spasticity) that may occur due to various conditions affecting the nervous system.
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Take it with or after food or a glass of milk.
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Mecab 750 may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
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Avoid consuming alcohol when taking Mecab 750 as it may cause excessive drowsiness.
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Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
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Do not stop taking it suddenly without talking to your doctor if you’ve been on it for a long time.
IV Administration
Direct IV: Administer undiluted at not to exceed 3 mL (=300 mg undiluted)/min
Infusion: Dilute 1 g with up to 250 mL D5W or NS; avoid extravasation, since injection is hypertonic
Administer IV while in recumbent position
Maintain position 15-30 min following infusion
IM Administration
Not to exceed 500 mg (5 mL undiluted) should be given into each gluteal region
Oral
Muscle spasm
Adult: Initially: 1.5 g q6hr for 48-72 hours; not to exceed 8 g/day THEN decrease to 4-4.5 g/day divided q4-8hr
Parenteral
1 g IV/IM; additional doses at q8hr until PO; not to exceed 3 g/day
Total parenteral dose should not exceed 3 g/day for >3 days, unless treating tetanus; if condition persists, may repeat therapy after drug-free interval of 48 hr
Intravenous
Tetanus
Adult: Adjunct therapy: Initial 1-2 g IV injection (at 300 mg/min), THEN
Additional 1-2 g IV infusion for total dose of 3 g initially
May repeat 1-2 g IV q6hr until can give NG or PO
Total oral dosage of up to 24 g daily may be needed.
Elderly: Dose may need to be reduced by half.
Tetanus
15 mg/kg/dose IV q6hr PRN or 500 mg/m²/dose; not to exceed 1.8 g/m²/day for 3 days only
Muscle Spasm
<16 years: Safety and efficacy not established
>16 years: 1500 mg PO q6hr for 48-72 hours; not to exceed 8 g/day THEN decrease to 4-4.5 g/day divided q4-8hr
May cause drowsiness/dizziness; patients should not ingest alcohol or other CNS depressants
May take with food to avoid stomach upset
Half-life increases with hepatic impairment
IV formulation not for use in renal impairment (contains polyethylene glycol; injection rate should not exceed 3 mL/min
May interfere with screening tests for 5-HIAA and vanillylmandelic acid (VMA)
Use injection with caution in patients with a history of seizures
Sedative effects potentiated when used with other sedatives
Medication is poorly tolerated in the elderly
Pediatric IV dosing approved only for tetanus
Lactation: Not known if excreted in breast milk; use caution
Nausea, anorexia, fever, headache, blurred vision, lassitude, drowsiness, dizziness, restlesness, anxiety, confusion, convulsions; hypersensitivity reactions e.g. rashes, pruritus, urticaria, angiodema. Parenteral: Flushing and a metallic taste; incoordination, diplopia, nystagmus, vertigo; sloughing and thrombophloebitis at the site of inj.
Potentially Fatal: Parenteral: Syncope, hypotension, bradycardia, anaphylaxis.
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