Minocin 50

Introduction
Minocin 50 is an antibiotic medicine used to treat bacterial infections in your body. It is effective in some infections of the lungs, urinary tract, eyes, and others. It kills bacteria, which helps to improve your symptoms and cure the infection. Minocin 50 is also used to treat many sexually transmitted diseases and a skin condition known as acne. It may be taken with or without food. However, you should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back. Commonly seen side effects seen with this medicine include headache, dizziness, vomiting, nausea, diarrhea, and skin reaction on exposure to sunlight (photosensitivity). Avoid excessive sun exposure and use sunscreen and protective clothing when outdoors. These are usually temporary and subside with the completion of treatment. Consult your doctor if you find these side effects bother or worry you. Inform your doctor if you have any previous history of allergy to any antibiotic or liver or kidney problems before taking this medicine. You should also let your doctor know all other medicines you are taking as they may affect, or be affected by this medicine. Pregnant or breastfeeding women should consult their doctor before using it. It may blur your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

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Uses of Minocin 50
Bacterial infections
Side effects of Minocin 50
Common
Headache
Dizziness
Photosensitivity
Vomiting
Nausea
Itching
Diarrhea
How to use Minocin 50
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Minocin 50 may be taken with or without food, but it is better to take it at a fixed time.
How Minocin 50 works
Minocin 50 is an antibiotic. It stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions.
Quick Tips
Your doctor has prescribed Minoz OD 100 Capsule MR to cure your infection and improve symptoms.
Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
It may cause dizziness. Don’t drive or do anything that requires mental focus until you know how Minoz OD 100 Capsule MR affects you.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn’t stop or if you find blood in your stools.
Discontinue Minoz OD 100 Capsule MR and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
Susceptible infections, Acne, Asymptomatic meningococcal carriers, Uncomplicated gonorrhoea, Nongonococcal urethritis, Syphilis,
Administration
IV Preparation Reconstitute cryodessicated powder with 5 mL sterile water for injection Immediately dilute further with 500-1000 mL of 0.9% NaCl, dextrose solutions, dextrose and NaCl solutions, Ringer Injection, or Lactated Ringer Reformulated Minocin IV Allows for dilution with lower fluid volume After vial reconstitution, dilute further with 100-1000 mL of 0.9% NaCl, dextrose solutions, dextrose and NaCl solutions, or 250-1000 mL of Ringer or Lactated Ringer injections IV Administration Avoid rapid IV infusion Infuse over one hour Not to exceed 400mg in 24 hours Oral Administration May take with or without food Ingestion of food along with may help reduce the risk of esophageal irritation and ulceration Extended-release tablets or capsules: Swallow whole without chewing, crushing, or splitting Extended-release tablet: These tablets are scored and intended to split to give precise dose

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Adult Dose
Oral Susceptible infections Adult: 200 mg daily in divided doses. Acne Adult: 50 mg bid or 100 mg once daily. ?45 kg: 1 mg/kg once daily as modified-release preparation. Asymptomatic meningococcal carriers Adult: 100 mg bid for 5 days, followed by a course of rifampicin. Nongonococcal urethritis Adult: 100 mg 12 hrly for at least 7 days. Uncomplicated gonorrhoea Adult: Initially, 200 mg, followed by 100 mg 12 hrly for a min of 4 days, follow-up cultures should be done w/in 2-3 days after completion of therapy. Uncomplicated urethral gonorrhoea in men Adult: 100 mg 12 hrly for 5 days. Mycobacterium marinum infections Adult: 100 mg 12 hrly for 6-8 wk. Syphilis Adult: 200 mg initially, followed by 100 mg 12 hrly for 10-15 days. Intravenous Susceptible infections Adult: Initially, 200 mg followed by 100 mg 12 hrly. Max: 400 mg/day.

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Child Dose
Intravenous Susceptible infections Child: >8 yr Initially, 4 mg/kg, then 2 mg/kg 12 hrly not to exceed the usual adult dose. Oral Acne Vulgaris <12 years: Safety and efficacy not established Immediate-release products: 4 mg/kg PO initially (not to exceed 200 mg), THEN 2 mg/kg/day PO q12hr; not to exceed 400 mg/day Extended-release tablets: 1 mg/kg PO qDay Administer therapy for 12 weeks _ Renal Dose Renal impairment: Reduce dose or increase dosing interval. Max: 200 mg/day. Contraindication Documented hypersensitivity Mode of Action Minocycline inhibits protein synthesis by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria. It is active against Streptococcus aureus, Neisseria meningitidis, various enterobacteria, Acinetobacter, Bacteroides, Haemophilus and Nocardia spp., and some mycobacteria. Precaution Caution in significant renal impairment (may lead to azotemia, hyperphosphatemia, and acidosis; monitor BUN) Adjust dose if renal impairment occurs Anaphylaxis reported; discontinue use and institute supportive therapy Prolonged use may result in fungal or bacterial superinfection Lupus, hepatitis, and vasculitis autoimmune syndromes reported with use; discontinue if lupus symptoms occur and assess liver function tests; ANA and CBC Discontinue therapy if pseudomembranous colitis occurs Risk of vestibular reactions Caution in hepatic impairment; discontinue if liver injury occurs Photosensitivity may occur with prolonged exposure to sunlight or tanning equipment; use skin protection and avoid prolonged exposure to sunlight Reduce dose in renal impairment; consider drug serum level determinations in prolonged therapy Tetracycline use during tooth development (last half of pregnancy through age 8 years) can cause tooth enamel hypoplasia or permanent teeth discoloration; more common with long-term use and with repeated, short courses; during pregnancy, may retard skeletal development and reduce bone growth Fanconi-like syndrome may occur with outdated tetracyclines Lightheadedness and vertigo may occur; use caution when performing tasks that require mental alertness or operating heavy machinery May increase BUN secondary to antianabolic effects Cases of drug rash with eosinophilia and systemic symptoms (DRESS) reported, some fatal; discontinue immediately _ Side Effect Discoloration of teeth (in children) Vestibular symptoms (>30%) Pericarditis Myocarditis Vasculitis Angioedema Alopecia Erythema nodosum Erythematous rash Exfoliative dermatitis Pruritus Toxic epidermal necrolysis Urticaria Dizziness Fever Fatigue Somnolence Angioedema Hyperpigmentation of nails Pigmentation of skin and mucous membranes Thyroid dysfunction Thyroid discoloration Thyroid cancer Vulvovaginitis Hemolytic anemia Neutropenia Thrombocytopenia Agrunolocytosis Pancytopenia Hepatic cholestasis Hepatitis Hyperbilirubinemia Jaundice CNS effects Clostridium difficile diarrhea

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Pregnancy Category Note
Pregnancy category: D Lactation: Enters breast milk, some manufacturers say do not nurse; however AAP considers nursing compatible due to calcium chelation of drug and prevention of its absorption; long-term safety of prolonged exposure unknown

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Interaction
Impaired absorption by concomitant admin w/ Ca-containing antacids and other divalent or trivalent cations (e.g. Al, bismuth, Fe, Mg, Zn). May decrease effectiveness of oral contraceptives. May interfere w/ the bactericidal action of penicillins. May potentiate the effect of anticoagulants. Increased risk of nephrotoxicity w/ diuretics. Increased risk of pseudotumour cerebri w/ retinoids (e.g. isotretinoin). Increased risk of ergotism w/ ergot alkaloids. Potentially Fatal: Concurrent use w/ methoxyflurane may result to fatal renal toxicity.

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