Medicine Overview of Nesudil 0.02%/3ml Drop
Elevated Intraocular Pressure
Indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension
Instill 1 drop in the affected eye(s) qDay in the evening
Dual inhibitor of Rho kinase and the norepinephrine plasma membrane transport protein
Increases trabecular outflow
Bacterial keratitis associated with use of multiple-dose containers of topical ophthalmic products; containers had been inadvertently contaminated by patients who had a concurrent corneal disease or a disruption of the ocular epithelial surface
Remove contact lenses prior to instilling ophthalmic solution; may reinsert lenses 15 minutes following administration
>10%
Hyperemia (53%)
~20%
Corneal verticillata
Instillation site pain
Conjunctival hemorrhage
1-10%
5-10%
Instillation site erythema
Corneal staining
Blurred vision
Increased lacrimation
Erythema of eyelid
Reduced visual acuity
Pregnancy
Data are not available on use in pregnant women to inform of any drug associated risk; however, systemic exposure to netarsudil from ocular administration is low
IV administration of netarsudil to pregnant rats and rabbits during organogenesis did not produce adverse embryofetal effects at clinically relevant systemic exposures
Lactation
No data on the presence in human milk, the effects on the breastfed infant, or the effects on milk production
Systemic exposure to netarsudil following topical ocular administration is low, and unknown whether measurable levels of netarsudil would be present in maternal milk following topical ocular administration
Reviews
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