Open 500

Introduction
Open 500 is an antibiotic used to treat a variety of bacterial infections, like, infections of the throat, ear, nasal sinuses, respiratory tract, skin and soft tissues. It is also used in the treatment of sexually transmitted diseases such as syphilis. Open 500 is also used to prevent some infections such as Rheumatic fever and infection of the heart valves (bacterial endocarditis) in people with pre-existing heart disease. It is a penicillin-type of antibiotic, which mainly fights and stops the growth of the gram-positive type of bacteria. This tablet should be swallowed empty stomach with a glass of water. It should be used regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening. The total duration of treatment and precise dosage will be decided by your doctor, depending on the type of infection that you have and how well you respond to the medication. Before taking this medicine, inform your doctor if you are allergic to penicillin or any penicillin-type of medicine. Rash, vomiting, allergic reactions, nausea and diarrhea may be seen as side effects in some patients. These are temporary and usually resolve quickly. Consult your doctor if any of these side effects persist or if your condition worsens. This medicine is generally regarded as safe to use during pregnancy if used under a doctor’s supervision.

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Uses of Open 500
Bacterial infections
Syphilis
Side effects of Open 500
Common
Rash
Vomiting
Allergic reaction
Nausea
Diarrhea
How to use Open 500
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Open 500 is to be taken empty stomach.
How Open 500 works
Open 500 is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Quick Tips
You have been prescribed Open 500 for the treatment of bacterial infections.
Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn’t stop or if you find blood in your stools.
Inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking this medicine.
Brief Description
Indication
Tonsillitis, Pharyngitis, Skin & soft tissue infections, Anthrax, Lyme disease, Rheumatic fever, Spleen disorders, Dental Abscesses, gingivitis, upper respiratory tract, scarlet fever, erysipelas, otitis media, Vincent’s infection

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Adult Dose
Oral Adult: Usually 250-500 mg 6 hourly Prophylaxis of recurrent rheumatic fever 250 mg twice daily. Streptococcal infections of the upper respiratory tract, including scarlet fever and erysipelas 125-250 mg 6-8 hrly for 10 days. Pneumococcal infections of the respiratory tract, including otitis media 250-500 mg 6 hrly until patient is afebrile for at least 2 days. Fusospirochetosis (Vincent’s infection) of the oropharynx; Staphylococcal infections of the skin and soft tissue 250-500 mg 6-8 hrly.

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Child Dose
Oral Tablet Children: PO 25–50 mg/kg/day q6h Syrup Dry Syrup: 1-2 tea-spoonful (5-10ml) 6 hourly Forte Syrup: ½-1 tea-spoonful (2.5-5ml) 6 hourly Infants: 62.5-125 mg 6 hourly

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Contraindication
Hypersensitivity to penicillins.
Mode of Action
Inhibits the biosynthesis of cell wall mucopeptide; bactericidal against sensitive organisms when adequate concentrations are reached, and most effective during the stage of active multiplication; inadequate concentrations may produce only bacteriostatic effects.
Precaution
Monitor renal and haematologic systems periodically during prolonged therapy or if high dose is used. Use may result in overgrowth of nonsusceptible organisms. Cross-sensitivity with cephalosporins may occur. History of significant allergies and/or asthma. Pregnancy and lactation.
Side Effect
Nausea, vomiting, epigastric distress, diarrhoea, black hairy tongue; skin eruptions (maculopapular to exfoliative dermatitis), urticaria and other serum-sickness like reactions, laryngeal oedema; fever, eosinophilia. Potentially Fatal: Anaphylaxis.

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