Orofer

Indication
Iron, Folic acid, Vitamin-C deficiency, Pregnancy and lactation
Administration
For maximum absorption take on empty stomach, but may take with or after meals to minimize GI irritation
Adult Dose
1 tablet daily. In more severe cases, 2 tablets a day may be required.
Contraindication
Contraindicated in patients with a known hypersensitivity to any of the ingredients of this product.
Mode of Action
Iron: Essential component in the formation of hemoglobin; adequate amounts of iron are necessary for effective erythropoiesis; also serves as a cofactor of several essential enzymes, including cytochromes that are involved in electron transport. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin. Folic acid: Required for nucleoprotein synthesis and the maintenance of normal erythropoiesis; folic acid is converted in the liver and plasma to its metabolically active form, tetrahydrofolic acid, by dihydrofolate reductase; prevents neural tube defects in women of childbearing potential and higher doses required during pregnancy. Zinc: Cofactor in over 100 enzymes; plays a role in DNA synthesis; supports a healthy immune system; helps maintain a sense of smell and taste; may assist in porper function of insulin. Vitamin C is necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in conversion of folic acid to folinic acid.

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Precaution
Caution should be taken in the conditions where there is a risk of iron overload, such as haemochromatosis, thalassemia, haemosiderosis or haemolytic anaemia. Lactation: Present in breast milk, use caution

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Side Effect
A few side-effects of oral iron preparations, including nausea, vomiting, constipation or diarrhoea may occur.
Interaction
Elemental iron: Antacids may decrease the absorption of carbonyl iron. Folic acid: Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides may result to decrease in serum folate contrations. Decreases serum phenytoin concentrations. Vit C: Deferroxamine, hormonal contraceptives, flufenazine, warfarin, elemental iron, salicylates, warfarin, fluphenazine, disulfiram, mexiletine, vitamin B12.

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