Polytracin

Indication
Bacterial ocular infections
Adult Dose
Adult: Ophth Ocular infections; Prevention of ocular infection following surgical procedure: Apply ½ inch 3-4 hrly for acute infections or 2-3 times/day for mild-to-moderate infections for 7-10 days. Treatment should be continued for another 2 days after the eye has apparently recovered.

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Child Dose
Child: Apply ½ inch ribbon in the affected eye(s) every 3-4 hr for acute infections or 2-3 times/day for mild-to-moderate infections for 7-10 days. Treatment should be continued for another 2 days after the eye has apparently recovered.
Contraindication
Hypersensitivity.
Mode of Action
Bacitracin, inhibits bacterial cell wall synthesis and is active against many gram-positive bacteria (e.g. staphylococci, streptococci, corynebacteria and clostridia) and some gram-negative species (e.g. Neisseria and Haemophilus influenzae). They are often found in combinations in topical preparations as broad spectrum antibacterial agents. Polymyxin B disrupts the bacterial cytoplasmic membrane of mostly gm-ve organisms allowing leakage of intracellular constituents by binding to membrane phospholipids.

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Precaution
Ointment may blur vision. Prolonged use of the antibacterial preparation may cause overgrowth of non-susceptible organisms, including fungi. Pregnancy and lactation. Lactation: Excretion in breast milk unknown; use caution

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Side Effect
<1% Allergic contact dermatitis,Conjunctival erythema,Swelling,Itching,Burning _ Pregnancy Category Note Pregnancy Category: C Lactation: unknown if distributed in breast milk _ Interaction Bacitracin Zinc: Increased risk of nephrotoxicity when used with other nephrotoxic drugs. May enhance the action of neuromuscular-blocking agents. Polymixin B: Potentially Fatal: Additive neurotoxic or nephrotoxic effect w/ bacitracin, streptomycin, neomycin, kanamycin, gentamicin, tobramycin, amikacin, cephaloridine, paromomycin, viomycin, colistin. Increased risk of resp paralysis w/ neuromuscular blockers (e.g. anaesthetics, muscle relaxants). _