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Prodol

Name: Prodol
SKU: SKU-FdlyhlSQ
Availability: InStock

Tablet - 325mg+37.5mg

Benham Pharmaceuticals Ltd.

Generic: Paracetamol + Tramadol Hydrochloride

10 Tablets (1 Strip)

Original price was: Tk. 80.Current price is: Tk. 71.

Description

Medicine Overview of Prodol 325mg+37.5mg Tablet

Introduction

Prodol is a pain relieving medicine. It is used in various conditions such as muscle ache, back pain, joint pain, menstrual cramps, and toothache.

Prodol can be taken with or without food. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it.

Using this medicine may cause few common side effects such as nausea, vomiting, constipation, weakness, and dryness in mouth. If you experience any such side effects that do not go away or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. In general, you should try to use the smallest amount necessary to control your symptoms.

Before using the medicine, you should tell your doctor if you have any other medical conditions or disorders. It may also affect, or be affected by, some other medicines you are using so let your doctor know all the other medicines you are taking. It should be used with caution in patients who are alcoholic or have liver or kidney disease. Pregnant and breastfeeding women should consult their doctors first before using the medicine.

Uses of Prodol

Pain relief

Side effects of Prodol

Common

Nausea
Vomiting
Constipation
Weakness
Dizziness
Dryness in mouth
Sleepiness

How to use Prodol

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prodol may be taken with or without food, but it is better to take it at a fixed time.

How Prodol works

Prodol is a combination of two medicines: Paracetamol/Acetaminophen and Tramadol. Paracetamol/Acetaminophen is an analgesic (pain reliever) which works by blocking the release of certain chemical messengers that cause pain. Tramadol is an opioid analgesic (pain reliever) which works by blocking the transmission of pain signals to the brain to lower pain perception.

Quick Tips

Use only for severe acute pain for not more than 5 days.

Prolonged use may result in physical and psychological dependence even at recommended dosages.

It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery.

It is better to take with food to avoid an upset stomach.

Your doctor may adjust your dose if you have liver or kidney disease.

In case of overdose, tell your doctor immediately.

Brief Description

Indication

Moderate to severe pain

Administration

May with or without food.

Adult Dose

Oral
Moderate to severe pain
Adult: 1-2 tab 6 hrly.
Max: 8 tab/day. Max duration: 5 days.

Hepatic impairment: Moderate: Increase dosing interval. Severe: Contraindicated.

Child Dose

Not recommended in child under 18 years of age.

Renal Dose

Renal impairment:
CrCl (ml/min) Dosage Recommendation
10-30 Increase dosing interva to 12 hr.ly
<10 Not recommended.

Contraindication

Hypersensitivity to tramadol, paracetamol or opioids. Situations where opioid use may be contra-indicated (e.g. acute intoxication with alcohol, hypnotic drugs, centrally-acting analgesics, opioids or psychotropic drugs). Severe hepatic impairment, uncontrolled epilepsy. Concurrent use or within 2 wk of discontinuation from MAOIs.

Mode of Action

Tramadol is a centrally acting opioid analgesic which binds to mu-opioid receptors and weakly inhibits the reuptake of norepinephrine and serotonin. Paracetamol, a para-aminophenol derivative, has analgesic, antipyretic and weak anti-inflammatory activity. Together, tramadol and paracetamol has faster onset of action compared to tramadol alone and longer duration of action compared to paracetamol alone.

Precaution

Patient w/ epilepsy controlled by treatment, risk of seizure, cranial trauma, biliary tract disorder, altered state of consciousness for unknown reasons, problems affecting the resp centre or resp function, increased intracranial pressure, suicidal tendency or patients in a state of shock. Not a suitable substitute in opioid-dependent patients. May cause withdrawal symptoms, dependence and abuse. Severe renal impairment. Elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor pain relief, resp rate, BP, and pulse rate; signs of tolerance, abuse, or suicidal ideation.

Side Effect

Postural hypotension, resp depression, hepatotoxicity, Stevens-Johnson syndrome, toxic epidermal necrolysis, bradycardia, collapse, allergic reactions w/ resp symptoms (e.g. dyspnoea, bronchospasm, wheezing, angioneurotic oedema), changes in appetite, motor weakness, changes in mood, activity, cognitive and sensorial capacity; exacerbation of asthma, withdrawal symptoms (e.g. agitation, anxiety), skin rash, blood dyscrasias, hypoprothrombinemia.

Potentially Fatal: Severe anaphylactic reactions.

Interaction

Increased risk of seizures and serotonin syndrome w/ SSRIs, SNRIs, TCAs, and 5-HT agonists (e.g. sumatriptan). Increased CNS depression w/ barbiturates, benzodiazepines, other anxiolytics, hypnotics, sedative antidepressants, sedative antihistamines, neuroleptics, centrally-acting antihypertensive drugs, thalidomide and baclofen. Decreased analgesic efficacy w/ ondansetron. Increased INR w/ warfarin.

Potentially Fatal: Increased risk of seizure and serotonin sydrome w/ MAOIs.