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Prostalex

Tablet - 250mg
Generic: Flutamide
1 Tablet

Description

Medicine Overview of Prostalex 250mg Tablet

Introduction

Prostalex is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It works by blocking the effects of male hormones such as testosterone.

Prostalex should be taken with or without food, preferably at a fixed time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Breast enlargement in males, sleepiness, nausea, and vomiting are some very common side effects of this medicine. Other than this, yellowing of skin, loss of appetite, shortness of breath, abdominal pain, dark urine, and skin rashes are some side effects that require immediate action. Regular blood tests are required to check your blood cells along with liver function during treatment with this medicine. It makes your skin more sensitive towards sunlight, hence take extra caution while going out.

Before taking it, tell your doctor if have diabetes, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You may be asked for regular monitoring of blood glucose level while on treatment.

Uses of Prostalex
  • Prostate cancer
Side effects of Prostalex
Common
  • Breast enlargement in male
  • Sleepiness
  • Nausea
  • Abdominal pain
  • Anemia (low number of red blood cells)
  • Breast tenderness
  • Constipation
  • Decreased appetite
  • Decreased libido
  • Depression
  • Dizziness
  • Indigestion
  • Flatulence
  • Hot flashes
  • Increased liver enzymes
  • Rash
  • Weakness
  • Weight gain
How to use Prostalex
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prostalex may be taken with or without food, but it is better to take it at a fixed time.
How Prostalex works
Prostalex blocks the effect of the natural male hormones on the growth of prostate cells. Prostalex also blocks the undesired effects of androgens in females such as excessive hair growth and acne.
Quick Tips
  • You have been prescribed Prostalex for the treatment of prostate cancer.
  • Take it with or without food, preferably at the same time every day.
  • Do not drive or do anything requiring concentration unless you know how Prostalex affects you.
  • It may cause your skin to become light sensitive. Avoid direct exposure to excessive sunlight and use sunscreen when outdoors.
  • If you are diabetic, monitor your blood glucose regularly while taking Prostalex.
  • Your doctor may want you to have regular blood tests to monitor your liver function while you are taking this medicine. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Do not stop taking the medication without talking to your doctor first.
Brief Description
Indication
Prostate cancer
Administration
May be taken with or without food.
Adult Dose

Oral
Palliative treatment of prostatic carcinoma
Adult: 250 mg tid preferably at least 3 days before gonadorelin analogue treatment.

Contraindication
Hypersensitivity, severe hepatic impairment, pregnancy and lactation.
Mode of Action
Flutamide is a nonsteroidal ‘pure’ antiandrogen which acts directly on the target tissues either by blocking androgen uptake or by inhibiting cytoplasmic and nuclear binding of androgen.
Precaution

Perform liver function tests before starting treatment and at regular intervals. Treatment is not recommended in patients whose ALT values exceed twice the upper limit of normal. Regular assessment of prostate specific antigen level may help to monitor disease progression. Advise patient against discontinuing drug on their own. Exercise caution in patients with cardiac disease.

Lactation: Excretion in milk unknown; not recommended

Side Effect

>10%
Hot flashes (61%),Decreased libido (36%),Impotence (31%),Diarrhea (12%),Nausea/vomiting (11%)

1-10%
Gynecomastia (9%),Anorexia (4%),Edema (4%),Leukopenia (3%),Rash (3%)

Frequency Not Defined
Hemolytic anemia, methemoglobinemia
Increased AST, ALT, bilirubin, BUN

Pregnancy Category Note

Pregnancy Category: D

Lactation: Excretion in milk unknown; not recommended

Interaction
Increased prothrombin time in patients on long-term warfarin treatment.
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