Medicine Overview of Remcor IV Infusion 5mg/ml Injection
Remcor IV Infusion is a multi-purpose antiviral medicine. It is used to treat suspected or laboratory-confirmed coronavirus disease 2019 (COVID-19) in adults and children admitted to the hospital with severe disease. The medication decreases the viral load in the body and increases the healing process. Remcor IV Infusion works by inhibiting RNA polymerase, an RNA-dependent enzyme that allows the SARS-CoV-2 virus to replicate itself. It is administered via injection into veins under the guidance of a doctor. You should only use Remcor IV Infusion if your doctor has prescribed it. Take it just as prescribed by your doctor. Remcor IV Infusion should not be taken on your own.
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- Nausea
- Vomiting
- Diarrhea
- Headaches
- Rashes
- Increased liver enzymes
It must be administered via intravenous infusion only. Do not administer by any other
route.Recommended Rate of Infusion- Diluted Remdesivir for Injection Lyophilized Powder in Adults and Pediatric Patients Weighing > 40 kg
Infusion bag 250 ml:
Infusion Time: 30 min, Rate of Infusion: 8.33 ml/min
Infusion Time: 60 min, Rate of Infusion: 4.17 ml/min
Infusion Time: 120 min, Rate of Infusion: 2.08 ml/min
Infusion bag 100 ml:
Infusion Time: 30 min, Rate of Infusion: 3.33 ml/min
Infusion Time: 60 min, Rate of Infusion: 1.67 ml/min
Infusion Time: 120 min, Rate of Infusion: 0.83 ml/min
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Adults requiring invasive mechanical ventilation and/or ECMO should receive a single loading dose of Remdesivir 200 mg on day one, followed by a once-daily maintenance dose of Remdesivir 100 mg for 9 days.
The recommended dose for adults who do not require invasive mechanical ventilation or ECMO is a single dose of Remdesivir 200 mg on day one, followed by a once-daily maintenance dose of Remdesivir 100 mg for four days. If a patient dose does not show clinical improvement, treatment may be extended for up to 5 more days (for a total of 10 days).
Remdesivir will be administered intravenously in a total volume of up to 250 mL 0.9% saline over 30 to 120 minutes.
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Higher risk of transaminase elevations.
Risk of decreased antiviral activity when combined with chloroquine phosphate or hydroxychloroquine sulfate. Hypersensitivity Including Infusion-related and Anaphylactic Reactions. Increased Risk of Transaminase Elevations. Risk of Reduced Antiviral Activity When Co-administered with Chloroquine Phosphate or
Hydroxychloroquine Sulfate.
Pregnancy:
It may be unsafe to take when pregnant. Although there have been few human research, animal studies have revealed negative impacts on the growing fetus.Before prescribing it to you, your doctor will consider the advantages and hazards.Please consult your doctor.
Lactation:
There is no information available about the presence of Remdesivir in human milk, the effects on breastfed infants, or the effects on milk production. Because of the risk of viral transmission of SARS-CoV-2 negative infants and adverse drug reactions in breastfeeding infants, the developmental and health benefits of breastfeeding should be considered alongside the mother’s clinical need for Remdesivir and any potential adverse effects on the breastfed child from Remdesivir or the underlying maternal condition.
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phosphate or hydroxychloroquine sulfate is not recommended use with remdesivir.
There have been no human drug-drug interaction trials with it and other medications. Remdesivir and its metabolites can act as substrates or inhibitors of enzymes and transporters involved in drug metabolism in vitro. The clinical relevance of these in vitro assessments is not established.
Please do not reuse or save any unused Remdesivir Lyophilized powder, injection solution, or diluted solution for infusion for future use. This product has no preservatives.
Lyophilized Powder:Remdesivir for injection, 100 mg, vials should be stored at a temperature of no more than 30°C in a dry place until ready for use. Protect from light and moisture. Don’t use after the expiration date.
After reconstitution, vials can be kept at room temperature for up to 4 hours (20°C-25°C) or refrigerated for 24 hours (2°C-8°C). Please dilute on the same day as administration.
Diluted Solution for Infusion: Should be stored at room temperature for up to 4 hours (20°C-25°C) or refrigerated for 24 hours (2°C-8°C).
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