Reumacap 25

Name: Reumacap 25
SKU: SKU-M3WzvewA
Availability: InStock

Capsule - 25mg

Aristopharma Limited

Generic: Indomethacin

10 Capsules (1 Strip)

Original price was: Tk. 10.Current price is: Tk. 9.

Description

Medicine Overview of Reumacap 25mg Capsule

Introduction

Reumacap 25 helps in relieving moderate pain and reducing fever. It effectively alleviates pain and inflammation in conditions like rheumatoid arthritis, osteoarthritis, gout and ankylosing spondylitis. Reumacap 25 should be taken in the dose and duration as advised by your doctor. It should be taken with food or milk to prevent stomach upset. Inform your doctor if you have any history of heart disease or stroke. Vomiting, stomach pain, nausea and indigestion are some of the common side effects that might be observed on taking this medicine. It may also cause dizziness, drowsiness or visual disturbances. Your doctor may regularly

Uses of Reumacap 25

Pain relief

Side effects of Reumacap 25

Common

Vomiting
Stomach pain/epigastric pain
Nausea
Indigestion
Diarrhea
Heartburn
Loss of appetite

How to use Reumacap 25

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Reumacap 25 is to be taken with food.

How Reumacap 25 works

Reumacap 25 is a non-steroidal anti-inflammatory drugs (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).

Quick Tips

You have been prescribed Reumacap 25 to relieve pain and inflammation.

Take it with food or milk to prevent upset stomach.

Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.

It may cause dizziness, drowsiness or visual disturbances. Use caution while driving or doing anything that requires concentration.

Avoid consuming alcohol while taking Reumacap 25 as it can cause excessive drowsiness and increase your risk of stomach problems.

Inform your doctor if you have a history of heart disease or stroke.

Your doctor may regularly monitor your kidney function, liver function and levels of blood components, if you are taking this medicine for long-term treatment.

Brief Description

Indication

Rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis (degenerative joint disease), gout, acute non-articular rheumatism (bursitis, synovitis, tendinitis).

Administration

Take with food to avoid gastrointestinal (GI) effects

Adult Dose

Oral
Inflammatory/Rheumatoid Disorders
Immediate release: 25-50 mg PO q8-12hr; not to exceed 200 mg/day
Extended release: 75-150 mg/day PO in single daily dose or divided q12hr; not to exceed 150 mg/day

Bursitis/Tendinitis
Immediate-release: 75-150 mg/day PO divided q6-8hr
Extended-release: 75-150 mg/day PO in single daily dose or divided q12hr

Acute Gouty Arthritis
50 mg PO q8hr for 3-5 days; reduced once pain is under control

Rectal
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: As supp: 100 mg to be inserted at night and repeated in the morning if necessary.

Child Dose

Inflammatory/Rheumatoid Disorders
<2 years: Safety and efficacy not established

2-14 years: 1-2 mg/kg/day PO divided q6-12hr; not to exceed 4 mg/kg/day or 150-200 mg/day

>14 years: 25-50 mg IR PO q8-12hr; not to exceed 200 mg/day;
75-150 mg/day ER PO in single daily dose or divided q12hr; not to exceed 150 mg/day

Contraindication

Indomethacin is contraindicated in patients with ulcer, gastritis, active ulcerative colitis, and should be used with caution in patients with a history of these disorders. It is also contraindicated in previously hypersensitive patient.

Mode of Action

Indometacin, an indole acetic acid derivative has anti-inflammatory, analgesic and antipyretic actions. It reversibly inhibits cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors.

Precaution

Patient w/ known CV disease or risk factors for CV disease, fluid retention, history of GI disease (e.g. bleeding or ulcers), history of mental depression or other psychiatric disorder, epilepsy, or parkinsonian syndrome; existing infection that is adequately controlled. May mask signs and symptoms of infection. Hepatic and renal impairment. Elderly, childn. Pregnancy and lactation.

Lactation: Drug enters breast milk; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing)

Side Effect

>10%
Transient renal insufficiency (40%),Jaundice (<15%),Elevated liver function test values (≤15%),Headache (12%)

1-10%
Dizziness (3-9%),Dyspepsia (3-9%),Epigastric pain (3-9%),Indigestion (3-9%),Nausea (3-9%)
Symptomatic upper GI ulcers, gross bleeding/perforation (4% of patients treated for 1 year; 1% of patients treated for 3-6 months).
Abnormal pain/cramps/distress (<3%),Constipation (1-3%),Depression (1-3%),Diarrhea (1-3%),Fatigue (1-3%),Somnolence (1-3%),Tinnitus (1-3%),Vertigo (1-3%)

<1%
Acute interstitial nephritis with hematuria/proteinuria,Acute respiratory distress,Agranulocytosis,Angioedema,Aplastic anemia,Asthma,Bone marrow depression,Congestive heart failure (CHF),Hemolytic anemia,Leukopenia,Macular and morbilliform eruptions,Pulmonary edema,Thrombocytopenia,Thrombocytopenic purpura,Ulcerative stomatitis,Urticaria

Interaction

May increase plasma levels of methotrexate. Increased risk of GI bleeding w/ warfarin. May reduce hypotensive effects of hydralazine, furosemide, ?-blockers (e.g. atenolol, propranolol, oxprenolol), or thiazide diuretics. Increased risk of hyperkalaemia w/ K-sparing diuretics, ACE inhibitors, K supplements. May increase nephrotoxic effects of ciclosporin or triamterene. Increase plasma concentration w/ probenecid. May increase plasma levels of aminoglycoside (e.g. amikacin, gentamicin) in premature neonates. May enhance antipsychotic effect (e.g. severe drowsiness and confusion) of haloperidol. Al- or Mg-containing antacids may reduce GI disorders of indometacin. Potentially Fatal: Diflunisal decreases renal clearance and increases plasma concentrations of indometacin which leads to