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Reumazin

Name: Reumazin
SKU: SKU-5BgDfKCd
Availability: InStock

Tablet - 500mg

Aristopharma Limited

Generic: Sulfasalazine

10 Tablets (1 Strip)

Original price was: Tk. 52.Current price is: Tk. 46.

Description

Medicine Overview of Reumazin 500mg Tablet

Introduction

Reumazin is a medicine used to treat various inflammatory conditions of the joints (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis), skin (psoriasis), and bowel (ulcerative colitis, Crohn’s disease).

Reumazin is to be taken with food. This will help you prevent an upset stomach. You should take it regularly and at the same time each day to get the maximum benefit from it. Keep taking it as recommended by your doctor and complete the dose even if you feel better. Taking it with plenty of water can help you avoid kidney problems such as kidney stones.

Using this medicine may cause some common side effects such as nausea, headache, loss of appetite, vomiting, diarrhea, weight loss, and gastrointestinal discomfort. You should consult with your doctor if any of these side effects do resolve with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking this medicine, let your doctor know if you have any problem with your heart, kidneys, or liver. Also, tell your doctor about all the other medicines you are taking. Your doctor may recommend regular blood tests to check your kidney and liver functions, and blood components. Pregnant and breastfeeding mothers should consult with their doctors before taking the medicine.

Uses of Reumazin

Rheumatoid arthritis
Ulcerative colitis
Crohn’s disease
Ankylosing spondylitis

Side effects of Reumazin

Common

Diarrhea
Gastrointestinal discomfort
Headache
Loss of appetite
Nausea
Oligospermia (low sperm count)
Vomiting
Weight loss

How to use Reumazin

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Reumazin is to be taken with food.

How Reumazin works

Reumazin is a Disease Modifying Anti-Rheumatoid Drug (DMARD). It works by suppressing the overactivity of the immune system in autoimmune diseases and blocks the chemical messengers that cause inflammation (swelling).

What if you forget to take Reumazin?

If you miss a dose of Reumazin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

Take it with food to avoid an upset stomach.

It may take 6-8 weeks for Sazo 500 Tablet DR to work. Keep taking it as prescribed.

Drink plenty of fluids while taking Sazo 500 Tablet DR in order to avoid kidney problems such as kidney stones.

It may cause a deficiency of folic acid. Take the supplements as suggested by the doctor.

Do not take Sazo 500 Tablet DR if you are allergic to sulfa drugs or aspirin.

It may discolour your skin, urine, saliva and tears an orange/yellow colour. This is normal and not harmful.

Regular blood tests to monitor your liver function, kidney function, and the levels of your blood components are required while taking this medicine.

Do not stop taking the medication suddenly without talking to your doctor.

Brief Description

Indication

Inflammatory bowel disease, Rheumatoid arthritis

Administration

Should be taken with food. Take after meals. Ensure adequate fluid intake.

Adult Dose

Oral
Inflammatory bowel disease
Adult: Initially, 1-2 g 4 times daily until remission occurs. Maintenance: 2 g/day in divided doses.

Rheumatoid arthritis
Adult: As enteric-coated tablet: Initially, 500 mg daily for the 1st wk increased by 500 mg every wk. Max: 3 g daily in 2-4 divided doses.

Rectal
Inflammatory bowel disease
Adult: As suppository: 0.5-1 g in the morning and night, either alone or as an adjunct to oral treatment.

Hepatic impairment: Avoid use.

Child Dose

Oral
Inflammatory bowel disease
Child: >2 yr: 40-60 mg/kg/day in divided doses. Maintenance: 20-30 mg/kg/day in divided doses.

Rheumatoid arthritis
Child: For polyarticular juvenile rheumatoid arthritis: >6 yr: As enteric-coated tablet: 30-50 mg/kg/day in 2 divided doses. Begin treatment with 1/4 to 2/3 of expected maintenance dose and increase wkly to reach maintenance dose in 1 mth. Max: 2 g daily.

Rectal
Inflammatory bowel disease
Child: As suppository (may be given as divided doses): 5-8 yr: 500 mg bid; 8-12 yr: 500 mg in the morning and 1 g at night; 12-18 yr: 1 g bid.

Renal Dose

Renal impairment:
CrCl (ml/min) Dosage Recommendation
10-30ml/min Admin twice daily.
<10ml/min Admin once daily.

Contraindication

Hypersensitivity to sulphonamides or salicylates, porphyria, <2 yr of age, intestinal or urinary obstruction, blood dycrasias, history of leucopenia with gold therapy.

Mode of Action

Actual mechanism not determined. Sulphasalazine may have direct anti-inflammatory action in the colon. It also systemically interferes with secretion by prostaglandin synthesis inhibition.

Precaution

Hepatic/renal impairment, G6PD deficiency, allergic bronchial asthma, lactation.

Lactation: Excreted into human breast milk; caution with breastfeeding, some reports of bloody stools or diarrhea in human milk fed infants of mothers taking sulfasalazine

Side Effect

>10%
Anorexia (~33%),Headache (~33%),Nausea (~33%),Vomiting (~33%),Gastric distress (~33%),Apparently reversible oligospermia (~33%)

<1%
Skin rash,Pruritus,Urticaria,Fever,Heinz body anemia,Hemolytic anemia,Cyanosis

Potentially Fatal: Severe hypersensitivity reactions, blood dyscrasias, renal and hepatic toxicity, fibrosing alveolitis.

Pregnancy Category Note

Pregnancy category: B; D if used for prolonged periods or near term; increased potential for kernicterus in the newborn

Interaction

Plasma levels reduced by rifampicin and ethambutol. Interferes with absorption of folic acid. Additive leucopaenia with gold therapy for rheumatoid arthritis. Increased haematological toxicity with azathioprine. Reduced serum levels of digoxin.